ArticleAnalytical and bioanalytical chemistry2026
Whole-body mass spectrometry imaging reveals metabolome and lipid peroxidation heterogeneity in zebrafish xenografts of esophageal squamous cell carcinoma.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Esophageal squamous cell carcinoma (ESCC) is a highly prevalent malignancy in China. Understanding its metabolic heterogeneity is of great significance for improving the precision of diagnosis and treatment. This study innovatively employed an adult zebrafish xenograft model, combining the spatial metabolomics and in situ derivatization method for fatty acid peroxidation products (FAPPs) based on air flow-assisted desorption electrospray ionization-mass spectrometry imaging (AFADESI-MSI) technology, to elucidate the metabolic patterns associated with ESCC and its differentiation grade. Spatial metabolomic data demonstrated that abundance alterations of glycerophospholipids and acetylated amino acids were statistically correlated with ESCC tumor formation. Levels of lysophospholipids and arachidonic acid-associated metabolites tended to increase with the progressive malignant differentiation of tumor lesions. Profiling of FAPPs showed elevated short- and medium-chain species accompanied by decreased long-chain counterparts in tumor-bearing zebrafish, which may be linked to tumor-initiated alterations in oxidative stress. Specifically, short- and medium-chain FAPPs were enriched in well-differentiated ESCC tissues, while long-chain FAPPs predominated in poorly differentiated tumors, suggestive of disparate lipid peroxidation patterns in ESCC cells at different differentiation stages. Furthermore, distinct signature metabolites were found to be specifically accumulated in the brain providing experimental clues that ESCC may remotely disturb the central nervous system metabolism of host animals. This research uncovers both tumor-induced and differentiation-dependent metabolic heterogeneity of ESCC, and validates whole-body MSI as a transformative approach to unravel tumor-host metabolic interactions.
Indexed as
Identifiers
42400651What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.