Evidence map›Paper›PMID 42400654›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2026

Effects of xanomeline-trospium on the gut-lung microbiota axis and susceptibility to LPS-induced acute lung injury in male and female mice.

Xin Ding, Akifumi Eguchi, Rumi Murayama, Yi Cai, Yong Yue, Jian-Jun Yang, Kenji Hashimoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xin DingChiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.
Akifumi EguchiDepartment of Sustainable Health Science, Center for Preventive Medical Sciences, Chiba University, Chiba, 263-8522, Japan.
Rumi MurayamaChiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.
Yi CaiChiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.
Yong YueChiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.
Jian-Jun YangDepartment of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. yjyangjj@126.com.
Kenji HashimotoChiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan. hashimoto@faculty.chiba-u.jp.ORCID https://orcid.org/0000-0002-8892-0439

Funding

National Natural Science Foundation of China U23A20421 and 82171189
6 · The paper itself

Abstract

Xanomeline-trospium is a first-in-class muscarinic receptor-based antipsychotic that improves schizophrenia symptoms without dopamine D

Indexed as

Acute Lung InjuryGastrointestinal MicrobiomeLungMicrobiotaAnimalsBenzilatesDisease Models, AnimalDisease SusceptibilityDrug CombinationsFemaleLipopolysaccharidesMaleMiceMice, Inbred C57BLNortropanesSex CharacteristicsBenzilatesDrug CombinationsLipopolysaccharidesNortropanesThiadiazolesxanomeline, trospium drug combinationAcute lung injuryGut-lung axisMicrobiotaMuscarinic receptor signalingSex differences

Identifiers

PMID42400654
PMCPMC13562288

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.