ArticleFish physiology and biochemistry2026
MiR-8159-x and miR-200-z induced liver injury of tsinling lenok trout through endoplasmic reticulum and mitochondria interaction under high-temperature stress.
Article in Fish physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
MicroRNAs (miRNAs) are crucial in animal stress responses. While some studies have investigated miRNA regulatory mechanisms, limited research exists on miRNAs involved specifically in stress caused by high temperatures. To explore the regulatory mechanism of miRNA in tsinling lenok trout under high-temperature stress. MiR-8159-x and miR-200-z were selected as candidates for further investigation. These candidates were identified through bioinformatics analysis of small RNA sequencing data obtained from tsinling lenok trout. Bioinformatics research indicates that miR-8159-x may target IRE1α, BAX, Cytc, and CxⅢ, while miR-200-z may target PERK, ATF4, and BIM. The analysis of RT-qPCR indicated a noteworthy reduction in the expression levels of miRNAs in the high-temperature stress group when compared to the control group. Conversely, the expression of target genes displayed an opposite pattern. Luciferase reporter gene assay demonstrated that the binding of miRNAs to the target genes caused a notable reduction in luciferase activity. The findings presented suggest that miR-8159-x and miR-200-z play a role in the stress reaction experienced by tsinling lenok trout when exposed to elevated temperatures.
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