Evidence map›Paper›PMID 42401032›Full record

ArticleMolecular pharmacology2026

Regulation of organic anion transporting polypeptide 1B1 transport function by lysine deacetylase 6.

Vikram Aditya, Vishakha Tambe, Pascaline Niyonshuti, Ruhul Kayesh, Erik J Soderblom, Xiaohong Mary Zhang, Chao Xu, Wei Yue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vikram AdityaDepartment of Pharmaceutical Sciences, University of Oklahoma Health Campus, Oklahoma City, Oklahoma.
Vishakha TambeDepartment of Pharmaceutical Sciences, University of Oklahoma Health Campus, Oklahoma City, Oklahoma.
Pascaline NiyonshutiDepartment of Pharmaceutical Sciences, University of Oklahoma Health Campus, Oklahoma City, Oklahoma.
Ruhul KayeshDepartment of Pharmaceutical Sciences, University of Oklahoma Health Campus, Oklahoma City, Oklahoma.
Erik J SoderblomProteomics and Metabolomics Core Facility, Duke University School of Medicine, Durham, North Carolina.
Xiaohong Mary ZhangDepartment of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan.
Chao XuDepartment of Biostatistics and Epidemiology, University of Oklahoma Health Campus, Oklahoma City, Oklahoma.
Wei YueDepartment of Pharmaceutical Sciences, University of Oklahoma Health Campus, Oklahoma City, Oklahoma. Electronic address: wei-yue@ou.edu.

Funding

Tissue Pathology and Biospecimen Shared ResourceP30CA225520 · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2025 to 2025
$2.2M
Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitorsR01GM146956 · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2025 to 2025
$290k
Targeting USP10 to regulate the DNA damage response in NSCLCR21CA256423 · NCI · WAYNE STATE UNIVERSITY · PI GEROLD BEPLER, Xiaohong Mary Zhang · 2022 to 2022
$176k
NCI NIH HHS P30 CA225520NCI NIH HHS R21 CA256423NIGMS NIH HHS R01 GM094268NIGMS NIH HHS R01 GM146956NIH HHS S10 OD024999
6 · The paper itself

Abstract

Hepatic transport protein organic anion transporting polypeptide 1B1 (OATP1B1) is a key determinant of drug-drug interactions. We reported OATP1B1 lysine acetylation recently, however, the lysine deacetylase (KDAC), also known as histone deacetylase (HDAC), involved in its deacetylation remains uninvestigated. This study determined the role of KDAC6/HDAC6, a major cytosolic KDAC, on OATP1B1 acetylation and transport function. Loss-of-function of KDAC6 by CRISPR/Cas9-mediated knockout in HEK293T cells or by treatment with the selective KDAC6 inhibitor tubacin (TBC) (5 μM, 24 hours) in transporter-expressing HEK293 cells markedly reduces OATP1B1-mediated transport of [

Indexed as

Histone Deacetylase 6Liver-Specific Organic Anion Transporter 1AcetylationAnilidesBiological TransportEstradiolHEK293 CellsHumansHydroxamic AcidsLysineProtein Processing, Post-TranslationalAnilidesEstradiolestradiol-17 beta-glucuronideHDAC6 protein, humanHistone Deacetylase 6Hydroxamic AcidsLiver-Specific Organic Anion Transporter 1LysineSLCO1B1 protein, humantubacinDrug–drug interactionDrug transportersLysine acetylationLysine/Histone deacetylase 6OATP1B1Phosphorylation

Identifiers

PMID42401032
PMCPMC13421777

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.