ArticleScientific reports2026
Mathematical modeling of peritoneal buffer transport and acidosis correction in patients on peritoneal dialysis.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Assessing buffer base kinetics in dialysate using the three-pore model of peritoneal transport is not enough to predict changes to the acid-base equilibrium in blood during peritoneal dialysis (PD). We complemented the three-pore model with a model of acid-base homeostasis to evaluate differences between PD sessions using dialysis fluid buffered with lactate (PD4) or bicarbonate/lactate (B/L). Six patients underwent two 4-hour dwells with either B/L or PD4; blood and peritoneal fluid sampling was used to quantify intraperitoneal volume-using a radioiodinated albumin as volume marker-and solute concentrations. The integrated model describes CO
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