Evidence mapPaperPMID 42402170Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

IL-33/ST2 Signaling Sustains Hepato-Intestinal Homeostasis by Orchestrating Vascular Surveillance and Immune Regulatory Circuits During Experimental Trypanosoma cruzi Infection.

Marcelo Eduardo Cardozo, Tatyane Martins Cirilo, José Bryan da Rocha Rihs, Jorge Lucas Nascimento Souza, Isabela de Brito Duval, Ana Rafaela Antunes-Porto, Luisa Vitor Braga do Amaral, Fernando Bento Rodrigues Oliveira, Mayra Fernanda Ricci, Laura Lis de Oliveira Santos and 13 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Marcelo Eduardo CardozoLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0009-0000-4337-625X
Tatyane Martins CiriloLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
José Bryan da Rocha RihsLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Jorge Lucas Nascimento SouzaLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Isabela de Brito DuvalLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Ana Rafaela Antunes-PortoLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Luisa Vitor Braga do AmaralLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Fernando Bento Rodrigues OliveiraLaboratory of Immunoregulation of Infectious Diseases, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Mayra Fernanda RicciLaboratory of Immunoregulation of Infectious Diseases, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Laura Lis de Oliveira SantosLaboratory of Immunoregulation of Infectious Diseases, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Lívia Fernanda Dias SantanaLaboratory of Immunoregulation of Infectious Diseases, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Luiza Pinheiro SilvaLaboratory of Immunoregulation of Infectious Diseases, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Chiara Cássia Oliveira AmorimLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Gabriela Gomes Monteiro LemosLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Getulío Mota E Silva JuniorLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Izabela da Silva OliveiraLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Marina Possa Dos ReysLaboratory of Comparative Pathology, Institute of Biological Sciences, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Ana Laura Grossi de OliveiraLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Geovanni Dantas CassaliLaboratory of Comparative Pathology, Institute of Biological Sciences, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Luisa Mourão Dias MagalhãesLaboratory of Interactions in ImmunoParasitology, Institute of Biological Sciences, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Lilian Lacerda BuenoLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0003-3510-4590
Fabiana Simão MachadoPost-Graduation Program in Health Sciences: Infectious Diseases and Tropical Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0002-4713-575X
Ricardo Toshio FujiwaraLaboratory of Immunobiology and Parasite Control, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0001-9272-5209

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 302491/2017-1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 305514/2022-9Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 307828/2022-0Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 310311/2023-3Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 421392/2018-5Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) APD-01254/25Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) APQ-01816-23Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) APQ-02628-24Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) APQ-04574-25Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) CBB APQ-00766-18Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) RED-00067-23Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) RED-00096-22INCT Dengue and Host-Microbial Interactions 408527/2024-2INCT Mucosas e Pele 408484/2024-1Pró-Reitoria de Pesquisa of the Universidade Federal de Minas GeraisREMITRIBIC RED-00031-21
6 · The paper itself

Abstract

Chagas disease, caused by Trypanosoma cruzi, is characterized by a complex interplay between parasite persistence and host-driven immunopathology. Although the IL-33/ST2 axis is known to regulate type 2 immunity and tissue repair, its contribution to tissue homeostasis during chronic infection remains poorly understood. Using ST2-deficient (ST2

Indexed as

Chagas DiseaseHomeostasisInterleukin-1 Receptor-Like 1 ProteinInterleukin-33IntestinesLiverSignal TransductionTrypanosoma cruziAnimalsDendritic CellsMaleMiceMice, Inbred BALB CMice, KnockoutIl1rl1 protein, mouseIl33 protein, mouseInterleukin-1 Receptor-Like 1 ProteinInterleukin-33CD44Chagas diseaseimmunopathologypatrolling monocytesvascular homeostasis

Identifiers

PMID42402170
PMCPMC13333159

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.