Evidence map›Paper›PMID 42402367›Full record

ArticleJournal of obesity & metabolic syndrome2026

Steatotic Liver Disease Predicts Lower Likelihood of LDLR Gene Mutations in Young Korean Patients with Suspected Familial Hypercholesterolemia.

Chang In Han, Sung Hyun Cho, Keungmo Yang, Hyun Yang, Si Hyun Bae, Jaejun Lee

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of obesity & metabolic syndrome, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Chang In HanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Armed Forces Goyang Hospital, Goyang, Korea.ORCID 0009-0004-4308-239X
Sung Hyun ChoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Armed Forces Goyang Hospital, Goyang, Korea.
Keungmo YangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Hyun YangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Si Hyun BaeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jaejun LeeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID 0000-0003-4402-9350

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Familial hypercholesterolemia (FH) is underdiagnosed in young adults, and universal genetic testing is costly. We evaluated whether steatotic liver disease (SLD) could predict low-density lipoprotein receptor (LDLR) mutations in suspected FH. Methods: We retrospectively analyzed 111 Korean military personnel aged 19-30 years who underwent LDLR sequencing and SLD assessment using controlled attenuation parameter (CAP) and hepatic steatosis index. Results: Pathogenic LDLR variants were identified in 23.4% of participants. Compared with non-carriers, carriers had lower CAP values (245.2 dB/m vs. 273.9 dB/m, Conclusion: SLD was inversely associated with genetically confirmed FH. Incorporating SLD assessment may help prioritize genetic testing in populations with a high prevalence of SLD or limited access to sequencing resources.

Indexed as

Fatty LiverHyperlipoproteinemia Type IIMutationReceptors, LDLAdultFemaleGenetic Predisposition to DiseaseGenetic TestingHumansMaleMilitary PersonnelPrevalenceRepublic of KoreaRetrospective StudiesYoung AdultLDLR protein, humanReceptors, LDLControlled attenuation parameterFamilial hypercholesterolemiaGenetic testingLow-density lipoprotein receptorSteatotic liver disease

Identifiers

PMID42402367
PMCPMC13429824

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.