ReviewMicrosystems & nanoengineering2026
From single cell analysis to 3D micro physiological systems: microfluidic tools integrating cancer cell targets for delineating natural killer cell biology.
Review in Microsystems & nanoengineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Natural killer cell is a critical cell type in our immune system. Its therapeutic potential in the development of novel cancer immunotherapy has been emerging. Microfluidic technologies capable of manipulating small volumes of fluid through microchannels are emerging tools for advancing our knowledge of natural killer cell biology. However, the rationale behind microfluidic device design, material choice, and the precise engineering of in vitro microenvironments has yet to be systematically assessed through the lens of complex NK cell biology using cancer cells as targets for activation. This comprehensive review assesses microfluidic technologies designed for the study of NK cell phenotype/function at a single cell level, migration dynamics in the presence or absence of biochemical cues, natural killer-target cell interactions, and observation of sophisticated cellular behavior (infiltration/cytotoxicity) in multi-factorial complex microenvironments. Step by step advances in device complexity such as the integration of acellular hydrogels or multicellular co-culture systems highlight the emerging need for higher resolution analysis of natural killer cell properties at the single cell, tissue, and organ levels. The progression of microfluidic technologies for advancing knowledge of natural killer (NK) cell biological mechanisms within the last twenty years. Figure was generated using BioRender.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.