Evidence mapPaperPMID 42403031Full record

ReviewJournal of cellular biochemistry2026

Tricarboxylic Acid (TCA) Cycle Enzyme Alpha-Ketoglutarate Dehydrogenase (KGDH) as a Nexus for the Regulation of Macrophage Polarization.

Meijing Li, Ryan J Mailloux

Abstract readReview
In one paragraph

Review in Journal of cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Meijing LiSchool of Human Nutrition, McGill University, Ste Anne de Bellevue, Ste Anne de Bellevue, Quebec, Canada.
Ryan J MaillouxSchool of Human Nutrition, McGill University, Ste Anne de Bellevue, Ste Anne de Bellevue, Quebec, Canada.ORCID https://orcid.org/0000-0003-3986-9830

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2022-03240
6 · The paper itself

Abstract

Macrophage metabolism has been increasingly studied in recent years for its potential as a therapeutic target across multiple pathologies. In this article, we propose that the tricarboxylic acid (TCA) cycle enzyme alpha-ketoglutarate (KG) dehydrogenase (KGDH) serves as a nexus for regulating macrophage polarization toward pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes. This is achieved through modulation of mitochondrial hydrogen peroxide (mtH

Indexed as

InflammationKetoglutarate Dehydrogenase ComplexMacrophagesAnimalsCitric Acid CycleHumansHydrogen PeroxideSignal TransductionHydrogen PeroxideKetoglutarate Dehydrogenase Complex

Identifiers

PMID42403031
PMCPMC13334242

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.