Evidence map›Paper›PMID 42403108›Full record

ArticleMolecular reproduction and development2026

LASP1, a Novel Protein in Spermatozoa and Acrosome Reaction.

Alicia Bender, Kilian Andress, Michael R Boesl, Claudia Staib, Adriane Woehl-Wenigerkind, Burkhard Kneitz, Hendrik Bartolomaeus, Alma Zernecke, Elke Butt

Abstract read
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In one paragraph

Article in Molecular reproduction and development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alicia BenderInstitute for Experimental Biomedicine II, University Hospital Würzburg, Würzburg, Germany.
Kilian AndressInstitute for Experimental Biomedicine II, University Hospital Würzburg, Würzburg, Germany.
Michael R BoeslInstitute of Experimental Biomedicine I, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany.
Claudia StaibDepartment of Obstetrics and Gynaecology, University Medical Center Würzburg, Würzburg, Germany.
Adriane Woehl-WenigerkindDepartment of Obstetrics and Gynaecology, University Medical Center Würzburg, Würzburg, Germany.
Burkhard KneitzDepartment of Urology and Pediatric Urology, University Hospital Würzburg, Josef-Würzburg, Germany.
Hendrik BartolomaeusInstitute for Experimental Biomedicine II, University Hospital Würzburg, Würzburg, Germany.
Alma ZerneckeInstitute for Experimental Biomedicine II, University Hospital Würzburg, Würzburg, Germany.
Elke ButtInstitute for Experimental Biomedicine II, University Hospital Würzburg, Würzburg, Germany.ORCID 0000-0002-0429-3918

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LIM and SH3 protein 1 (LASP1) is a widely expressed scaffold protein associated with actin-rich structures. In Lasp1-knockout mice, reproductive defects such as longer intervals between litters and reduced pup numbers were observed. Consistently, data from the Human Protein Atlas show strong LASP1 expression in spermatids, suggesting a reproductive role. Mammalian fertilization involves sequential processes of sperm activation, capacitation, and acrosome reaction, driven by bicarbonate-mediated PKA activation, CNP-regulated PKG stimulation, F-actin polymerization, Ca

Indexed as

Acrosome ReactionAdaptor Proteins, Signal TransducingCytoskeletal ProteinsLIM Domain ProteinsSpermatozoaSperm CapacitationActinsAnimalsHomeodomain ProteinsHumansMaleMiceMice, KnockoutSperm ProteinsActinsAdaptor Proteins, Signal TransducingCytoskeletal ProteinsHomeodomain ProteinsLASP1 protein, humanLasp1 protein, mouseLIM Domain ProteinsSperm ProteinsCD44F‐actinLASP1protein kinase Gspermatozoa

Identifiers

PMID42403108
PMCPMC13334231

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.