ArticleiScience2026
High-definition transcranial direct current stimulation enhances exercise-induced hypoalgesia in patients with chronic low back pain.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise-induced hypoalgesia is often attenuated in chronic pain. This randomized, double-blind, sham-controlled trial tested whether HD-tDCS over the left primary motor cortex enhances exercise-related hypoalgesic responses, as reflected by pressure pain threshold changes, during aerobic exercise in chronic low back pain. Fifty-two participants received active or sham HD-tDCS while cycling. Pressure pain thresholds and pain-evoked fNIRS responses were assessed before and after intervention. Active HD-tDCS produced larger pressure pain threshold increases than sham stimulation and attenuated pain-evoked activation in somatosensory, motor, and prefrontal regions. Reduced cortical activation correlated with increased pressure pain thresholds, and reduced left dlPFC activation mediated the PPT increase at the tibialis anterior site. These findings suggest that M1 HD-tDCS can augment acute exercise-related pressure pain threshold responses and modulate pain-evoked cortical activity in chronic low back pain.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.