ArticleJournal of pharmaceutical analysis2026
β-Caryophyllene confers protection against type 2 diabetic osteoporosis by blocking ferroptosis via the AMPK/Nrf2 pathway.
Article in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Type 2 diabetic osteoporosis (T2DOP) is a chronic bone disorder marked by increased fracture risk and osteonecrosis, exacerbated by a persistent high-glucose and high-fat (HGHF) environment, distinguishing it from postmenopausal osteoporosis. Ferroptosis, an iron-dependent form of programmed cell death caused by lipid peroxidation, plays a crucial role in the death of bone marrow mesenchymal stem cells (BMSCs) due to glucolipotoxicity. β-Caryophyllene (BCP), a natural bicyclic sesquiterpene found in essential oils, shows extensive pharmacological promise for various diseases. This study investigated BCP's role and mechanisms in mitigating HGHF-induced ferroptosis. A murine T2DOP model was established via HGHF diet and streptozotocin (STZ) injection, while BMSCs were cultured under HGHF conditions to mimic diabetic pathology
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