Evidence map›Paper›PMID 42404106›Full record

ReviewJournal of hepatocellular carcinoma2026

Emerging Role of Sirtuins-Mediated Ferroptosis in Hepatocellular Carcinoma Progression: Mechanisms and Therapeutic Perspectives.

Jiangtao Bai, Xuefeng Bai, Jihong Yang, Guodong Yu, Yong Cui

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of hepatocellular carcinoma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiangtao Bai *Department of Interventional and Vascular Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, People's Republic of China.
Xuefeng Bai *Department of Hepatobiliary Surgery, Affiliated Hospital of Hebei University, Baoding, People's Republic of China.
Jihong YangDepartment of Hepatobiliary Surgery, Affiliated Hospital of Hebei University, Baoding, People's Republic of China.
Guodong YuDepartment of Hepatobiliary Surgery, Affiliated Hospital of Hebei University, Baoding, People's Republic of China.
Yong CuiDepartment of Hepatobiliary Surgery, Affiliated Hospital of Hebei University, Baoding, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) ranks as the most common type of primary liver cancer, characterized by rapid tumor growth and therapeutic resistance. Evading cell death is a key characteristic of multiple cancers, including HCC. Many programmed cell death (PCD) processes, comprising apoptosis, autophagy, necroptosis, and ferroptosis, have been identified to affect tumor growth and recurrence of HCC. Ferroptosis is an emerging iron-dependent PCD mode characterized by lipid peroxidation and iron accumulation. It has emerged as a critical regulatory mechanism in HCC progression. Sirtuins (SIRTs), a class III histone deacetylases (HDACs) that require NAD

Indexed as

ferroptosishepatocellular carcinomamolecular mechanismprogressionsirtuins

Identifiers

PMID42404106
PMCPMC13330767

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.