ArticleFrontiers in neurology
Quality of life and its influencing factors in patients with neuromyelitis optica spectrum disorder.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Neuromyelitis optica spectrum disorder (NMOSD) imposes a significant burden on health-related quality of life (HRQoL). However, comprehensive studies examining HRQoL and its biopsychosocial determinants in Chinese NMOSD patients remain scarce. Methods: In this cross-sectional study, 216 Chinese patients with NMOSD underwent clinical evaluation for neurological disability (EDSS) and completed a battery of standardized self-report measures. These scales assessed HRQoL (SF-36), basic activities of daily living (BADL), depressive symptoms (PHQ-9), anxiety (GAD-7), sleep quality (PSQI), psychological resilience (CD-RISC), perceived social support (PSSS), general alienation (GAS), and social avoidance and distress (SAD). Multiple stepwise linear regression analyses were employed to identify independent associated factors of the Physical (PCS) and Mental (MCS) Component Summaries of the SF-36. Results: The cohort (median age 37, 85.2% female) showed significantly reduced median PCS (55.5) and MCS (51.0), with role-physical (25.0) and role-emotional (33.3) most impaired. In multivariate analysis, older age ( Conclusion: Psychosocial factors critically influence HRQoL in Chinese NMOSD patients. Multidimensional, culturally sensitive interventions targeting mental health, sleep, and social functioning may provide insights for improving patient outcomes.
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