Evidence map›Paper›PMID 42404138›Full record

ReviewAnimal nutrition (Zhongguo xu mu shou yi xue hui)2026

Biological applications and future perspectives of bioactive compounds as pig feed additives.

Yang Hao, Yuqiang Qian, Da Liu, Fuhou Li, Hengzong Zhou, Minjun Jin, Chengcheng Li, Tianjia Liu, Dongxu Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yang HaoDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130117, Jilin, China.
Yuqiang QianDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130117, Jilin, China.
Da LiuChangchun University of Chinese Medicine, Changchun 130117, Jilin, China.
Fuhou LiDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130117, Jilin, China.
Hengzong ZhouDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130117, Jilin, China.
Minjun JinDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130117, Jilin, China.
Chengcheng LiDepartment of Animal Sciences and Aquatic Ecology, Faculty of Bioscience Engineering, Ghent University, Gent 9000, Belgium.
Tianjia LiuChangchun University of Chinese Medicine, Changchun 130117, Jilin, China.
Dongxu WangDepartment of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun 130117, Jilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Restrictions or prohibitions on the use of antibiotics in pig feed for growth promotion have been introduced in many countries. Bioactive compounds (BCs) as functional additives are emerging as an alternative to overcome these restrictions. These compounds include natural extracts from animals, plants, and microorganisms, as well as their chemically synthesized counterparts. Their growing popularity is due to their abundant sources, safety, and multiple biological functions, including antibacterial, antioxidant, anti-inflammatory, immunomodulatory, and intestinal health-promoting effects. This review summarizes the various types of BCs developed to date, including polyphenols, polysaccharides, aldehydes, terpenes, and polypeptides, and their use in pig production. It also discusses how these BCs can be used in pig farming, particularly to improve sows' reproductive performance, reduce diarrhea in piglets, and enhance the meat quality of finishing pigs. Despite these functions, the broader application of BCs remains limited due to the challenges such as poor water solubility, low stability, intestinal malabsorption, and low bioavailability. These challenges can potentially be addressed through emerging technologies, particularly nanotechnology, genetic engineering, and artificial intelligence. This review also highlights how these technologies may facilitate the translation of BCs into practical applications within commercial pig production. Finally, this review focuses on future perspectives of BCs in pig feed by exploring how advances in cell biology, materials science, and genetic engineering may interact to shape the future trajectory of BCs use in the pig industry.

Indexed as

Bioactive compoundDelivery systemGut health modulationNanoparticlePig

Identifiers

PMID42404138
PMCPMC13332473

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.