Evidence map›Paper›PMID 42404140›Full record

ArticleEuropean heart journal open2026

Sex-specific associations of perioperative Resolvin D1 and D2 dynamics with postoperative atrial fibrillation in cardiac surgery: a secondary analysis of a prospective observational study.

Melina Heine, Felix Ulbrich, Samuel Justice, Babak Saravi, Simon A Amacher, Julian Hubrich, Leonard Simeth, Asishana Osho, Charles N Serhan, Jochen D Muehlschlegel and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Melina HeineDepartment of Anesthesiology, Mass General Brigham, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.ORCID https://orcid.org/0009-0000-1911-3492
Felix UlbrichDepartment of Anesthesiology and Critical Care, Medical Center, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg im Breisgau, Germany.ORCID https://orcid.org/0000-0003-1175-9736
Samuel JusticeDepartment of Anesthesiology, Mass General Brigham, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0001-7193-4108
Babak SaraviDepartment of Oral, Maxillofacial and Facial Plastic Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Moorenstraße 5, 40225 Düsseldorf, Germany.ORCID https://orcid.org/0000-0003-2298-3696
Simon A AmacherDepartment of Anesthesiology and Critical Care, Medical Center, University of Freiburg, Hugstetter Str. 55, 79106 Freiburg im Breisgau, Germany.ORCID https://orcid.org/0000-0001-6530-1240
Julian HubrichDepartment of Anesthesiology, Mass General Brigham, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.
Leonard SimethDepartment of Anesthesiology, Mass General Brigham, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.ORCID https://orcid.org/0009-0008-9681-8646
Asishana OshoDivision of Cardiac Surgery, Mass General Brigham, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0002-1140-097X
Charles N SerhanDepartment of Anesthesiology, Mass General Brigham, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0003-4627-8545
Jochen D MuehlschlegelDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans St, Baltimore, MD 21287, USA.ORCID https://orcid.org/0000-0002-6209-7253
Jakob WollbornDepartment of Anesthesiology, Mass General Brigham, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0002-6767-7978

Funding

Evaluating Resolution Mechanisms for Infectious InflammationR35GM139430 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2021 to 2025
$3.6M
NIGMS NIH HHS R35 GM139430
6 · The paper itself

Abstract

Aims: Postoperative atrial fibrillation (POAF) is a prevalent and clinically significant complication that occurs after cardiac surgery. While inflammation has been linked to its onset, the role of active inflammatory resolution-mediated by a group of mediators named specialized pro-resolving mediators (SPMs)-remains unclear. Since SPMs, such as resolvins, actively terminate inflammation and restore tissue homeostasis, impaired resolution could contribute to persistent postoperative inflammation and the development of POAF. Methods: This study is a secondary analysis of a single-centre prospective cohort of 319 adult patients who underwent cardiac surgery. The occurrence of POAF was identified. Resolvin D1 (RvD1) and D2 (RvD2) levels were measured during the perioperative period. The association between resolvin levels and POAF was assessed using a mixed-effects Tobit regression model. The interaction between gender, POAF, and resolvin levels was furthermore investigated. Results: Patients who developed POAF exhibited significantly higher predicted perioperative levels of RvD1 [mean ratio (MR-interpreted analogously to an odds ratio): 1.19, Conclusion: POAF is associated with elevated RvD1 and reduced RvD2 levels, suggesting a differential response and potentially distinct roles of the two pro-resolving mediators in patients with POAF. Additionally, these associations differ by sex, indicating that inflammatory resolution mechanisms may vary between males and females. Registration: German Clinical Trials Registry (DRKS No. 00017057), Date of registration 5 April 2019, www.drks.de.

Indexed as

Cardiac surgeryInflammationInflammatory ResolutionPostoperative atrial fibrillationResolvins

Identifiers

PMID42404140
PMCPMC13332794

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.