ArticleTransplantation direct2026
Impact of Perfusion With Methylene Blue on Perioperative Bleeding in Simultaneous Pancreas and Kidney Transplantation: A Randomized Control Trial.
Article in Transplantation direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
14 authors.
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Abstract
Background: Simultaneous pancreas-kidney transplantation (SPK) is the optimal treatment for selected patients with type I diabetes mellitus (T1DM) and end-stage kidney disease, but intraoperative bleeding remains a major cause of morbidity. Methylene blue flush during back-table pancreas preparation may better help preemptively identify bleeding points and reduce complications. Methods: A single-center, single-blinded, prospective randomized control trial was conducted at Westmead Hospital over 30 mo. Sixty participants were randomized to receive either crystalloid (n = 33) or methylene blue (MB) flush (n = 27) during pancreas preparation before implantation. The primary outcome was intraoperative bleeding. Results: There was no significant difference in intraoperative blood loss with the use of MB flush (433 ± 385 mL versus 588 ± 382 mL; Conclusions: MB flush did not significantly reduce intraoperative blood loss but reduced intraoperative transfusion requirements, while increasing postoperative blood transfusion requirements, indicating a temporal shift in bleeding pattern. Graft outcomes were unaffected. Further studies should explore mechanisms and evaluate long-term outcomes.
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