ReviewInternational journal of general medicine2026
Vaginal Microecological Imbalance, Human Papillomavirus Infection, and Cervical Carcinogenesis: Mechanisms and Clinical Implications.
Review in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vaginal microecology serves as a critical barrier for female reproductive tract health, with its dysbiosis being closely linked to persistent HPV infection and the initiation and progression of cervical cancer. This review systematically outlines the composition and functions of the vaginal microbiota and delves into the multifaceted mechanisms by which microecological imbalance promotes human papillomavirus (HPV) acquisition, persistence, and oncogenic transformation. These mechanisms include dysregulation of local and systemic immunity, chronic inflammation, alterations in microbial metabolites, and disruption of the epithelial barrier. Furthermore, the article synthesizes recent advancements in novel strategies for cervical cancer prevention, auxiliary diagnosis, and treatment based on microecological modulation. The overarching aim is to provide a consolidated theoretical foundation and identify potential therapeutic targets for the precise prevention and management of cervical cancer, highlighting the pivotal role of maintaining or restoring vaginal microbial homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.