Evidence map›Paper›PMID 42404333›Full record

SynthesisFrontiers in sports and active living2026

Effects of exercise on cardiorespiratory fitness in individuals with MASLD: a systematic review and dose-response meta-analysis.

Wei Huang, Yifei He, Hainan Lu, Junyu Wang, Yixin Liang, Lizhaoxi Zeng, Lulu Li, Hongyu Lu, Zhihang Li, Ziyu Wang and 3 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in sports and active living, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wei Huang *Shanghai Customs University, Department of General Education, Shanghai, China.
Yifei He *Shanghai Changhai Hospital, Department of Endocrinology, Shanghai, China.
Hainan Lu *Shanghai Changhai Hospital, Department of Nutrition, Shanghai, China.
Junyu WangSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Yixin LiangSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Lizhaoxi ZengShanghai Customs University, Department of General Education, Shanghai, China.
Lulu LiShanghai Customs University, Department of General Education, Shanghai, China.
Hongyu LuShanghai Customs University, Department of General Education, Shanghai, China.
Zhihang LiShanghai Customs University, Department of General Education, Shanghai, China.
Ziyu WangShanghai Customs University, Department of General Education, Shanghai, China.
Yijun XieShanghai Customs University, Department of General Education, Shanghai, China.
Peng DuanShanghai Customs University, Department of General Education, Shanghai, China.
Jin LuShanghai Changhai Hospital, Department of Endocrinology, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cardiorespiratory fitness (CRF), primarily assessed via maximal oxygen uptake (VO₂max) or peak oxygen uptake (VO₂peak) during incremental exercise testing, is a robust predictor of cardiovascular mortality in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). However, the exercise volume associated with greater CRF gains in this population remains poorly defined. Therefore, this study aimed to evaluate the efficacy of supervised structured exercise on CRF in MASLD individuals and characterize the dose-response relationship using restricted cubic splines. Methods: We systematically searched PubMed, Embase, and Web of Science through July 18, 2025, for randomized controlled trials comparing supervised exercise with usual care in adults with MASLD. The primary outcome was CRF, measured as VO Results: Thirteen RCTs comprising 15 exercise-control comparisons involving 356 participants were included. Exercise significantly improved CRF compared with control conditions (SMD = 0.82, 95% CI: 0.54-1.10; I Conclusion: Exercise interventions improve CRF in individuals with MASLD. Exploratory dose-response analyses suggest that CRF gains may follow a non-linear pattern with increasing exercise volume, but the estimated peak points should be interpreted as model-based indicators rather than definitive prescription thresholds. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251243283, PROSPERO CRD420251243283.

Indexed as

aerobic exercisecardiorespiratory fitnessdose-response meta-analysisMASLDsupervised exercise

Identifiers

PMID42404333
PMCPMC13330729

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.