Evidence map›Paper›PMID 42404383›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

The Latin American Spanish PACC5 (LAS-PACC5): Advancing Cognitive Assessment in Latinos.

Nadeshka Ramirez-Perez, Isabel Solis, Lusiana Martinez, Nikole Bonillas Felix, Randy Medrano, Alexandre Ribas, George E Silva, Jairo E Martinez, Averi Giudicessi, Diana Munera and 6 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nadeshka Ramirez-PerezDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Isabel SolisDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Lusiana MartinezDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Nikole Bonillas FelixDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Randy MedranoDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Alexandre RibasDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
George E SilvaDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Jairo E MartinezDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Averi GiudicessiDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Diana MuneraDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Jorge AlcinaDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Clara Vila-CastelarDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Marta Gonzalez CatalanDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Liliana A Ramirez-GomezDepartment of Neurology Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA.
Daniel SaldanaDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.
Yakeel T QuirozDepartment of Psychiatry Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA.ORCID https://orcid.org/0000-0001-9714-8244

Funding

Boston Latino Aging Study (BLAST): Understanding Alzheimer's risk and biomarkers in older LatinosR01AG066823 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI QUIROZ, YAKEEL T. · 2021 to 2025
$4.2M
Resilience to Cognitive Decline and Resistance to Alzheimer's Disease and Related Neurodegenerative Diseases in Individuals from Colombia with Autosomal Dominant DementiasRM1NS132996 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI AGUILLON, DAVID FERNANDO, ARBOLEDA-VELASQUEZ, JOSEPH · 2023 to 2023
$3.8M
Nerve Growth (NGF) Factor Metabolic Dysfunction as a Marker of Cognitive Decline in Autosomal Dominant Alzheimer's DiseaseR01AG077627 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI David Fernando Aguillon, A CLAUDIO CUELLO · 2025 to 2026
$1.3M
Examining the impact of sex and hormones on the progression of autosomal dominant Alzheimer's diseaseK99AG073452 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI VILA CASTELAR, CLARA · 2022 to 2023
$268k
NIA NIH HHS K99 AG073452NIA NIH HHS R01 AG066823NIA NIH HHS R01 AG077627NINDS NIH HHS RM1 NS132996
6 · The paper itself

Abstract

introductionTo address the need for validated Spanish-language cognitive assessments in Latino populations at risk for Alzheimer's disease (AD), we evaluated the psychometric performance of a Latin American Spanish adaptation of the Preclinical Alzheimer's Cognitive Composite-5 (LAS-PACC5).

methodsA total of 121 Spanish-speaking older adults from the Boston Latino Aging Study (BLAST; Mean age = 64.98 ± 6.98 years; 69% female) were included. The LAS-PACC5 replaced literacy-dependent tasks with culturally and linguistically appropriate measures. Convergent validity was examined using measures validated in diverse Spanish-speaking populations.

resultsLAS-PACC5 showed moderate associations with naming ability, episodic memory, and global cognition (all DISCUSSION: The LAS-PACC5 demonstrated convergent and discriminative validity, supporting its utility for early cognitive assessment in Spanish-speaking older adults and for improving Latino representation in AD Research.

Indexed as

Alzheimer's diseasecognitive compositeearly detectionepisodic verbal memoryglobal cognitionLatino/a/e/xnaming

Identifiers

PMID42404383
PMCPMC13329757

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.