Evidence map›Paper›PMID 42404562›Full record

ArticleFrontiers in medicine2026

Lung transplantation from polytrauma donors: beyond primary graft dysfunction.

Chiara Catelli, Daniele Marianello, Andrea Lloret Madrid, Marianna Rizzo, Miriana D'Alessandro, Margherita Sambo, Francesca Montagnani, Marco Guerrieri, David Bennett, Elena Bargagli and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chiara CatelliThoracic Surgery and Lung Transplant Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Daniele MarianelloCardiothoracic and Vascular Anesthesia and Intensive Care Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Andrea Lloret MadridThoracic Surgery and Lung Transplant Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Marianna RizzoThoracic Surgery and Lung Transplant Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Miriana D'AlessandroDepartment of Life Sciences, Health and Healthcare Professions, Link Campus University, Rome, Italy.
Margherita SamboInfectious and Tropical Diseases Unit, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Francesca MontagnaniInfectious and Tropical Diseases Unit, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Marco GuerrieriRespiratory Diseases Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
David BennettRespiratory Diseases Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Elena BargagliRespiratory Diseases Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Piero PaladiniThoracic Surgery and Lung Transplant Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Federico FranchiCardiothoracic and Vascular Anesthesia and Intensive Care Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Luca LuzziThoracic Surgery and Lung Transplant Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lung donors are increasingly older and marginal. Polytrauma donors (PD) represent a potentially valuable resource due to their younger age, although trauma-related lung injury raises concerns regarding graft quality. This study aimed to evaluate early and mid-term outcomes after lung transplantation using lungs from PDs compared with non-polytrauma donors (NPD). Methods: We retrospectively analyzed 125 lung transplant recipients from brain-dead donors between January 2013 and June 2024. Perioperative outcomes, primary graft dysfunction (PGD), and pulmonary function at 1, 3, and 6 months were compared between PD ( Results: In the overall cohort, PDs were younger and more frequently male, with a higher prevalence of pulmonary contusions. Early postoperative outcomes, including PGD, ICU stay, and perioperative complications, were comparable between groups. At 6 months, overall survival was higher in the PD group (91.7 vs. 75.3%, Conclusions: Lung transplantation using grafts from polytrauma donors is not associated with worse perioperative or mid-term outcomes. After adjustment for baseline differences, outcomes were comparable to those from non-polytrauma donors, supporting the safe and selective use of these grafts as a strategy to expand the donor pool.

Indexed as

donor poollung transplantationpolytraumaprimary graft dysfunctionpulmonary function

Identifiers

PMID42404562
PMCPMC13327877

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.