ArticleDigital health
Rest-activity rhythmicity as digital biomarkers of postoperative recovery and complications in children.
Article in Digital health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Surgery and postoperative complications disrupt circadian rhythms. While clinicians recognize the implicit value of circadian rhythms to evaluate postoperative recovery, the absence of a practical means to measure them has limited their exploration and integration into clinical practice in children. Methods: Consumer wearable device (Fitbit) was given to children 3-18 years old who underwent laparoscopic appendectomy for complicated appendicitis and data were collected during postoperative days (POD) 1 to 21. Three novel rest-activity rhythmicity (RAR) metrics were computed from minute-by-minute continuous Fitbit data: (1) Periodicity and (2) Amplitude of the 24-hour Activity Rhythm; and (3) Circadian quotient of the 24-hour heart rate (HR) Rhythm. RAR trajectories were aggregated for patients without postoperative complications and compared against trajectories for patients with complications. Results: Ninety-four patients were included in the analysis (n=13 [14%] with complications). For patients without complications, three RAR metrics gradually increased in intensity until reaching plateaus between POD 11-20 (Periodicity of the 24-hour Activity Rhythm, 95% confidence interval [CI]: POD 9-14; Amplitude of the 24-hour Activity Rhythm, 95% CI: POD 16-24; Circadian quotient of the 24-hour HR Rhythm, 95% CI: POD 9-15). Although the RAR metrics for children with complications increased in intensity, none plateaued during the 21-day study period. Conclusion: Wearable-derived circadian rhythms demonstrated distinct patterns in RAR metrics for children with and without complications during the 21-day study period following appendectomy. This suggests that the RAR may be relevant digital biomarkers to track postoperative recovery and identify complications in pediatric populations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.