Evidence map›Paper›PMID 42404606›Full record

ReviewBMJ oncology2026

Beyond auto-segmentation: the case for planning and dosimetry AI in head and neck radiation oncology.

Abdulla Elkhadrawy, Sean J Choi, Edward Christopher Dee, Milit S Patel, Yingzhi Wu, Nadeem Riaz, Harini Veeraraghavan, Donghoon Lee, Sharif Elguindi, Nancy Y Lee

Abstract readReview
In one paragraph

Review in BMJ oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abdulla ElkhadrawyDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0009-0009-9108-0723
Sean J ChoiDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0009-0005-4034-9551
Edward Christopher DeeRadiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0001-6119-0889
Milit S PatelMemorial Sloan Kettering Cancer Center, New York, New York, USA.
Yingzhi WuDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Nadeem RiazDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Harini VeeraraghavanDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Donghoon LeeDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Sharif ElguindiDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Nancy Y LeeDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial intelligence (AI) has been rapidly integrated into radiation oncology workflows, with the most visible successes occurring in auto-segmentation of target volumes and organs at risk. While these advances have delivered meaningful efficiency gains and improved standardisation, their impact on clinical outcomes in head and neck cancer remains indirect. In head and neck radiotherapy, long-term toxicity and quality of life are influenced not only by contouring accuracy but more directly by nuanced dosimetric trade-offs during treatment planning. This narrative review synthesises the current landscape of AI applications in head and neck radiotherapy planning and highlights the limitations of a segmentation-dominated paradigm. We review the evolution of planning AI from knowledge-based statistical models to deep learning-based dose prediction and emerging reasoning-driven frameworks. We also aim to discuss how these approaches may function as complementary components of a broader planning intelligence ecosystem. In addition to potential patient-level benefits, we examine the system-level implications of planning and dosimetry AI. Finally, we outline key considerations for the safe evaluation and deployment of planning AI. Together, this review positions planning and dosimetry AI as an enabling infrastructure for predictive, adaptive and equitable head and neck radiotherapy.

Indexed as

Head and neck cancerRadiation oncology

Identifiers

PMID42404606
PMCPMC13331092

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.