ArticleJBMR plus2026
Influencing factors and early warning indicators for nonvertebral fractures in patients with Duchenne muscular dystrophy.
Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
Nonvertebral fractures (NVFs) in patients with Duchenne muscular dystrophy (DMD) are often associated with an unfavorable prognosis. However, the influencing factors and early warning indicators for NVFs remain unclear. To address this knowledge gap, a retrospective cohort study was conducted across 2 centers involving 295 DMD patients who were evaluated between August 2013 and February 2022. Data collection included telephone callback records and outpatient face-to-face assessments. Among the 295 patients, 30 (10.2%) had experienced at least 1 NVF. The overall NVF incidence rate was 91.8 (95% CI, 62.4-130.3) per 10 000 person-years, representing a rate more than 5 times higher than that of traumatic NVFs in boys aged 0-14 yr. This finding underscores the significant burden of NVFs in DMD patients. Subsequent analysis investigated the association between the occurrence of the first NVF and various factors, including ambulant status, glucocorticoid (GC) regimen, and dystrophin isoform expression. Multivariate analysis revealed that ambulation was a significant risk factor for the first NVF, with an increased risk of 29.2-fold (95% CI, 3.9-217.3,
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