ArticleFrontiers in immunology2026
Integrative genetic and expression profiling prioritizes
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Atherosclerosis shows vascular bed specificity, yet research has focused on coronary arteries, leaving the causal genetics and immune cell-specific mechanisms of carotid plaque (CP) unexplored. This study aims to unbiasedly identify CP candidate genes and evaluate their therapeutic potential. Methods: Two-sample MR analysis was performed using data from 14 peripheral blood immune cell types and two GWAS datasets for carotid plaque, followed by colocalization analysis to prioritize causal genes. A human carotid plaque single-cell RNA-seq dataset was then integrated to examine cellular expression patterns, cell-cell communication, and functional enrichment. Results: 22 candidate genes for CP were identified. Conclusion: Our integrative genetic and transcriptomic approach prioritizes
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.