ArticleCanadian liver journal2026
Low muscle mass predicts liver-related outcomes in cirrhosis, independent of portal hypertension: A retrospective cohort study.
Article in Canadian liver journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sarcopenia is associated with increased mortality in patients with cirrhosis, but this association remains unclear when adjusted for portal hypertension. We investigated the association of muscle mass and portal hypertension on liver-related events. Methods: This retrospective study (2012-2022) included adult patients with cirrhosis and available hepatic venous pressure gradient (HVPG). Total cross-sectional skeletal muscle index (SMI) and subcutaneous adipose tissue index (SATI) at the third lumbar vertebrae (L3) were measured at the time of HVPG using CT imaging. Sarcopenia is defined as L3-SMI <39 cm Results: A total of 121 patients were included (sarcopenia: 46%, female: 62%, mean age: 58.3 years, MASLD: 34%, median HVPG: 10 mmHg, median MELD score: 13, prior decompensation: 55%). Sarcopenia was more likely in patients with prior decompensation (70% versus 43%, Conclusions: Our study demonstrates that low muscle mass predicts liver-related events and mortality independently of portal hypertension and liver disease severity.
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