Evidence map›Paper›PMID 42405165›Full record

ArticleRSC advances2026

Directed evolution of a cytochrome P450 monooxygenase for improved perillyl alcohol biosynthesis

Catherine A Odhiambo, Alexandra A Malico, Gavin J Williams

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Catherine A OdhiamboDepartment of Chemistry, NC State University Raleigh North Carolina 27695 USA gjwillia@ncsu.edu.ORCID https://orcid.org/0000-0002-5761-5538
Alexandra A MalicoDepartment of Chemistry, NC State University Raleigh North Carolina 27695 USA gjwillia@ncsu.edu.
Gavin J WilliamsDepartment of Chemistry, NC State University Raleigh North Carolina 27695 USA gjwillia@ncsu.edu.ORCID https://orcid.org/0000-0003-2172-9063

Funding

NC STATE MOLECULAR BIOTECHNOLOGY TRAINING PROGRAM (MBTP)T32GM133366 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Jason M. Haugh, Robert M Kelly · 2020 to 2026
$3.3M
NC State Chemistry of Life Training Program (CLTP)T32GM141887 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI PIERCE, JOSHUA G. · 2021 to 2025
$1.3M
Directed Evolution of Isoprenoid BiosynthesisR01GM143450 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI WILLIAMS, GAVIN J · 2021 to 2024
$1.2M
NIGMS NIH HHS R01 GM143450NIGMS NIH HHS T32 GM133366NIGMS NIH HHS T32 GM141887
6 · The paper itself

Abstract

Perillyl alcohol is a naturally occurring terpene with promising anticancer properties. However, like other oxidized terpenes, its limited biosynthetic availability hinders its development as a therapeutic lead. Cytochrome P450 monooxygenase CYP153A6 catalyzes the key hydroxylation of limonene to yield perillyl alcohol in

Identifiers

PMID42405165
PMCPMC13329868

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.