Evidence map›Paper›PMID 42405271›Full record

ArticleEJHaem2026

Targeting CD162 for Life-Threatening Cutaneous Chronic Graft-Versus-Host Disease: A Case Report.

Alicia Lieberman, Ross McCauley, Maureen Ross, Philip McCarthy, Iming Cho, Simona Reed, Shih-Yao Lin, Judy Chou, Shernan G Holtan

Abstract read
In one paragraph

Article in EJHaem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alicia LiebermanRoswell Park Comprehensive Cancer Center Transplant and Cell Therapy Program Buffalo New York USA.
Ross McCauleyRoswell Park Comprehensive Cancer Center Transplant and Cell Therapy Program Buffalo New York USA.
Maureen RossRoswell Park Comprehensive Cancer Center Transplant and Cell Therapy Program Buffalo New York USA.
Philip McCarthyRoswell Park Comprehensive Cancer Center Transplant and Cell Therapy Program Buffalo New York USA.
Iming ChoAltrubio, Inc San Francisco California USA.
Simona ReedAltrubio, Inc San Francisco California USA.
Shih-Yao LinAltrubio, Inc San Francisco California USA.
Judy ChouAltrubio, Inc San Francisco California USA.
Shernan G HoltanRoswell Park Comprehensive Cancer Center Transplant and Cell Therapy Program Buffalo New York USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Steroid-refractory chronic cutaneous graft-versus-host disease (GVHD) causes substantial morbidity, prolonged hospitalization, and non-relapse mortality after allogeneic hematopoietic cell transplantation. We report a young adult with multisystem chronic GVHD and recurrent life-threatening inflammatory skin flares refractory to multiple standard therapies, with cumulative inpatient care exceeding 1 year. Under an institutional review board-approved compassionate-use protocol, he received a non-cytotoxic monoclonal antibody targeting CD162 (P-selectin glycoprotein ligand-1). Treatment was associated with durable resolution of active cutaneous GVHD, corticosteroid reduction, improved mobility, and meaningful recovery in daily function and quality of life. Trial Registration: The author has confirmed clinical trial registration is not needed for this submission.

Indexed as

case reportCD162‐targeted antibodychronic graft‐versus‐host diseasePSGL‐1skin GVHD

Identifiers

PMID42405271
PMCPMC13329829

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.