Evidence map›Paper›PMID 42405749›Full record

ArticleeLife2026

Activity-dependent CO

Jack Butler, Lowell Mott, Amol Bhandare, Angus Brown, Nicholas Dale

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jack ButlerSchool of Life Sciences, University of Warwick, Coventry, United Kingdom.ORCID 0000-0003-2985-6841
Lowell MottSchool of Life Sciences, University of Warwick, Coventry, United Kingdom.
Amol BhandareSchool of Life Sciences, University of Warwick, Coventry, United Kingdom.ORCID 0000-0002-5214-9355
Angus BrownThe University of Nottingham Medical School, Queen's Medical Centre, Nottingham, United Kingdom.ORCID 0000-0002-2903-324X
Nicholas DaleSchool of Life Sciences, University of Warwick, Coventry, United Kingdom.ORCID 0000-0003-2196-2949

Funding

Biotechnology and Biological Sciences Research Council BB/T00746X/1
6 · The paper itself

Abstract

Loss of function mutations of Cx32, which is expressed in Schwann cells, cause X-linked Charcot-Marie-Tooth disease, a slowly progressive peripheral neuropathy. Action potential propagation causes Cx32 hemichannels in the Schwann cell paranode to open. As Cx32 hemichannels are directly sensitive to CO

Indexed as

AxonsCarbon DioxideConnexinsSchwann CellsAction PotentialsAnimalsAquaporin 1Carbonic AnhydrasesGap Junction beta-1 ProteinGap Junction delta-2 ProteinMiceSciatic NerveAqp1 protein, mouseAquaporin 1Carbon DioxideCarbonic AnhydrasesConnexinsGap Junction beta-1 ProteinGap Junction delta-2 Proteincarbon dioxidecell biologyCharcot Marie ToothconnexinshemichannelmouseneuroscienceparanodeSchwann cell

Identifiers

PMID42405749
PMCPMC13336771

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.