Evidence map›Paper›PMID 42405960›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Silybin protects against ethanol-induced acute gastric ulcer in rats with PI3K/AKT-associated phosphorylation changes.

Haikun Li, Changci Tong, Xiang Li, Peifang Cong, Yunen Liu, Zhonghua Luo

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haikun LiCollege of Food Science, Shenyang Agricultural University, Shenyang, Liaoning, 110866, China.
Changci TongShuren International College, Shenyang Medical College, No. 146, Huanghe North Street, Shenyang, Liaoning, 110034, China.
Xiang LiShuren International College, Shenyang Medical College, No. 146, Huanghe North Street, Shenyang, Liaoning, 110034, China.
Peifang CongShuren International College, Shenyang Medical College, No. 146, Huanghe North Street, Shenyang, Liaoning, 110034, China.
Yunen LiuShuren International College, Shenyang Medical College, No. 146, Huanghe North Street, Shenyang, Liaoning, 110034, China. liuye990116@163.com.
Zhonghua LuoShuren International College, Shenyang Medical College, No. 146, Huanghe North Street, Shenyang, Liaoning, 110034, China. zhonghua_2398@163.com.

Funding

Shenyang Science and Technology Plan Project 22-315-6-117
6 · The paper itself

Abstract

This study evaluated the effects of silybin in a rat model of ethanol-induced acute gastric ulcer (AGU) using network pharmacology-guided pathway prioritization, molecular docking, and in vivo validation. Network pharmacology identified 48 computational candidate targets. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment mapped these targets to 20 pathways, and PI3K/AKT signaling was selected for experimental assessment. Docking analysis indicated that silybin could be accommodated in the selected PI3K and AKT binding pockets. In rats, oral silybin pretreatment reduced macroscopic ulceration and attenuated histological and ultrastructural injury after ethanol challenge. Silybin-treated rats also showed higher VEGF expression, lower iNOS expression, and increased p-PI3K/PI3K and p-AKT/AKT ratios. These results identify PI3K/AKT phosphorylation as a pathway-associated readout accompanying silybin-mediated gastroprotection.

Indexed as

Ethanol-induced acute gastric ulcerMolecular dockingNetwork pharmacologyPI3K/AKT signaling pathwaySilybin

Identifiers

PMID42405960

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.