Evidence map›Paper›PMID 42406110›Full record

ArticleCellular and molecular life sciences : CMLS2026

The BmCPV-derived viral small peptide vsp1S4(-) suppresses viral replication by triggering apoptosis via the ROS-JNK signalling pathway.

Xialing Chen, Xiaoyan Du, Lixuan Li, Yao Yao, Qian Teng, Haoni Xue, Min Zhu, Xing Zhang, Chengliang Gong, Xiaolong Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xialing Chen *School of Life Sciences, Soochow University, Suzhou, 215123, China.
Xiaoyan Du *School of Life Sciences, Soochow University, Suzhou, 215123, China.
Lixuan LiSchool of Life Sciences, Soochow University, Suzhou, 215123, China.
Yao YaoSchool of Life Sciences, Soochow University, Suzhou, 215123, China.
Qian TengSchool of Life Sciences, Soochow University, Suzhou, 215123, China.
Haoni XueSchool of Life Sciences, Soochow University, Suzhou, 215123, China.
Min ZhuSchool of Life Sciences, Soochow University, Suzhou, 215123, China.
Xing ZhangSchool of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou, 215009, China. xzhang2022@usts.edu.cn.
Chengliang GongSchool of Life Sciences, Soochow University, Suzhou, 215123, China. gongcl@suda.edu.cn.
Xiaolong HuSchool of Life Sciences, Soochow University, Suzhou, 215123, China. xlhu2013@suda.edu.cn.ORCID http://orcid.org/0000-0003-3689-6243

Funding

National Natural Science Foundation of China 31972620, 31602007
6 · The paper itself

Abstract

Viral antisense RNAs are generally considered noncoding. Here, we show that segment 4 of Bombyx mori cypovirus (BmCPV) encodes a 78-aa antisense-microprotein, vsp1S4(-), that triggers a host-restrictive reactive oxygen species (ROS)-c-Jun N-terminal kinase (JNK)-apoptosis axis. vsp1S4(-) localizes to mitochondria, induces superoxide release, and activates JNK signalling. Consequently, cells undergo caspase-3-dependent apoptosis and S-phase arrest, while the levels of the viral structural protein (VP7) and progeny virions are strongly suppressed. Pharmacologic interruption of either ROS with N-acetylcysteine (NAC) or JNK signalling with SP600125, a dominant-negative JNK effectively rescues VP7 expression and restores viral replication, confirming that vsp1S4(-)-elicited signalling shows antiviral activity. Thus, BmCPV autonomously limits its own propagation through an antisense-encoded peptide that weaponizes host mitochondrial ROS and JNK, representing a paradigm of programmed self-attenuation operating via antisense translation.

Indexed as

ApoptosisBombyxMAP Kinase Signaling SystemReactive Oxygen SpeciesReoviridaeViral ProteinsVirus ReplicationAnimalsJNK Mitogen-Activated Protein KinasesMicropeptidesMitochondriaSignal TransductionJNK Mitogen-Activated Protein KinasesMicropeptidesReactive Oxygen SpeciesViral ProteinsApoptosisBmCPVROS-JNK pathwayViral replicationvsp1S4(-)

Identifiers

PMID42406110
PMCPMC13620063

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.