Evidence map›Paper›PMID 42406274›Full record

ArticleJournal of endocrinological investigation2026

Inhibition of TGF-β1/Smad signaling reverses the dedifferentiated phenotype of thyroid cancer cells in three-dimensional culture.

Li Zhang, Wenjing Gao, Shichen Xu, Hongxun Wu, Yun Zhu, Botao Huang, Xian Cheng, Jing Wu, Huixin Yu, Jiandong Bao and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Li Zhang *National Health Commission Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China. zhangli@jsinm.org.ORCID http://orcid.org/0000-0002-1740-8833
Wenjing Gao *School of Life science and Technology, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, 210096, China.
Shichen XuNational Health Commission Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
Hongxun WuJiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
Yun ZhuJiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
Botao HuangJiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
Xian ChengNational Health Commission Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
Jing WuNational Health Commission Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
Huixin YuNational Health Commission Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
Jiandong BaoJiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
Zichao ZhangSchool of Life science and Technology, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, 210096, China. zhangzc@seu.edu.cn.ORCID http://orcid.org/0000-0001-5769-948X

Funding

National Natural Science Foundation of China 81972503National Natural Science Foundation of China 82103656
6 · The paper itself

Abstract

purposeThyroid cancer is the most common malignancy of the endocrine system, with a rising global incidence. Radioactive iodine (RAI) therapy with

Indexed as

3D spheroid culture modelsDedifferentiationGalunisertibTGF-β1/SmadThyroid cancer

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.