ArticleJournal of visualized experiments : JoVE2026
Assessing Transduction Efficiency And Cell Targeting By Cell-penetrating Peptides In The Mouse Lung.
Article in Journal of visualized experiments : JoVE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Cell-penetrating peptides (CPPs) are short peptides (5-30 amino acids) capable of crossing cell membranes and delivering macromolecular cargoes without the need for transfection reagents. However, defining in vivo. cellular selectivity requires validation at the cell-type level. An integrated workflow is presented to assess the transduction efficiency of a Cy5.5-labeled cyclized CPP, cR11A, within alveolar epithelial type II (AT2) cells following retro-orbital intravenous injection in mice. Lungs were harvested at 15 or 60 min post-injection and analyzed using complementary readouts, including paired-fraction fluorescence-activated cell sorting (FACS) to isolate Cy5.5⁺ and Cy5.5⁻ lung single-cell suspensions followed by single-cell RNA sequencing, flow cytometry of lung single cells from Sftpc-CreERT2
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.