ArticleVirus research2026
Transcriptome analysis of African swine fever virus I9R-mediated modulation of host antiviral immunity.
Article in Virus research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
African swine fever (ASF) is an acute hemorrhagic disease caused by African swine fever virus (ASFV), with mortality rates approaching 100% in domestic pigs. Because its genome is large and structurally complex, the functions of many ASFV encoded genes remain poorly understood. In this study, ASFV I9R was identified as a relatively conserved early transcribed gene. To investigate its biological role, an I9R deletion recombinant virus (ASFV-ΔI9R) was generated by replacing the I9R gene with an enhanced green fluorescent protein (EGFP) expression cassette. In primary porcine alveolar macrophages (PAMs), ASFV-ΔI9R and the parental ASFV CN/GS/2018-WT (ASFV-WT) exhibited identical replication kinetics, indicating that I9R is dispensable for viral replication in vitro. Transcriptome sequencing (RNA-seq) analysis of infected PAMs at 18 and 36 hour post infection (hpi) showed that differentially expressed genes (DEGs) in ASFV-ΔI9R-infected cells were mainly enriched in innate immune signaling pathways, particularly pathways associated with type I interferon (IFN-β) mediated antiviral responses. Further analyses demonstrated that ASFV-ΔI9R infection reduced IFN-β-induced the expression of interferon-stimulated gene 12A (ISG12A) and inhibited phosphorylation levels of STAT1 and STAT2, key components of the JAK-STAT signaling pathway. Collectively, these findings suggest that I9R is involved in modulation of host antiviral responses through the JAK-STAT signaling pathway. This study provides additional insights into ASFV host interactions and contributes to understanding the biological functions of ASFV encoded genes.
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