Evidence map›Paper›PMID 42409403›Full record

ArticleBMJ open2026

Impact of fertility preservation on quality of life, recurrence and reproductive success in young female cancer survivors: a Korean prospective multicentre cohort study protocol (LIFE-Repro).

Hyun-Woong Cho, Se Ik Kim, Jeong-Yeol Park, Jung Bok Lee, Chel Hun Choi, Jung-Yun Lee, Bo Hyon Yun, Myong Cheol Lim, Sung-Jong Lee, Kyung-Jin Min and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hyun-Woong ChoDepartment of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.ORCID http://orcid.org/0000-0002-0724-9971
Se Ik KimDepartment of Obstetrics and Gynecology, Seoul National University, Seoul, South Korea.
Jeong-Yeol ParkDepartment of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.ORCID http://orcid.org/0000-0003-2475-7123
Jung Bok LeeDepartment of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Chel Hun ChoiDepartment of Obstetrics and Gynecology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea.
Jung-Yun LeeDepartment of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, South Korea.
Bo Hyon YunDepartment of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, South Korea.ORCID http://orcid.org/0000-0001-5703-797X
Myong Cheol LimGynecologic Cancer Branch and Center for Uterine Cancer, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea.
Sung-Jong LeeDepartment of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul St Mary's Hospital, Seoul, South Korea.
Kyung-Jin MinDepartment of Obstetrics and Gynecology, College of Medicine, Korea University, Korea University Ansan Hospital, Ansan-si, South Korea.
Ji Geun YooDepartment of Obstetrics and Gynecology, The Catholic University of Korea, Daejeon St Mary's Hospital, Daejeon, South Korea.
Dong Hoon SuhDepartment of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, South Korea.ORCID http://orcid.org/0000-0002-4312-966X
Yunjung ChoiKorean Society of Gynecologic Oncology, Seoul, South Korea.
Jae-Weon KimDepartment of Obstetrics and Gynecology, Seoul National University, Seoul, South Korea kjwksh@snu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGynaecological cancers increasingly affect women of reproductive age, necessitating fertility-sparing treatments that balance oncological safety with reproductive potential. However, the long-term impact of these treatments on survivorship-specifically regarding sexual function, quality of life (QoL) and reproductive outcomes-remains understudied. LIFE-Repro is a prospective multicentre cohort study designed to evaluate these impacts in young female cancer survivors. METHODS AND ANALYSIS: Between 2023 and 2027, eleven tertiary referral hospitals in Korea will recruit 200 patients aged ≤45 years with gynaecological cancers who have undergone fertility-sparing treatment. Participants will undergo baseline assessments followed by prospective follow-ups every 6 months. At each visit, patient-reported outcomes assessing sexual function, QoL and health status will be collected using a mobile application developed by the research team. The primary endpoint is the incidence of post-treatment sexual dysfunction measured by the Female Sexual Function Index-Korean version. Secondary endpoints include longitudinal changes in QoL, cancer recurrence, survival, pregnancy rates, live birth rates and premature menopause. ETHICS AND DISSEMINATION: The study protocol was approved by the Institutional Review Board of Korea University Guro Hospital (2024GR0484). Results will be disseminated through peer-reviewed journals and conference presentations. TRIAL REGISTRATION NUMBER: KCT0009578.

Indexed as

Cancer SurvivorsFertility PreservationGenital Neoplasms, FemaleNeoplasm Recurrence, LocalQuality of LifeAdultFemaleHumansMiddle AgedPregnancyProspective StudiesRepublic of KoreaResearch DesignSexual Dysfunction, PhysiologicalYoung AdultCohort studyFertility preservationGynecologic neoplasmsQuality of lifeSexual dysfunctionSurvivorship

Identifiers

PMID42409403
PMCPMC13343081

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.