ArticleCell discovery2026
PRC1 nanoglobules organize Hox chromatin during Drosophila embryogenesis.
Article in Cell discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3.Nucleic acids research · 2026Article
- Polycomb Group Proteins inBiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Polycomb group (PcG) proteins are required to maintain the silencing of key developmental genes during development. In Drosophila, they bind to discrete genomic elements named Polycomb response elements (PREs). PcG proteins form two classes of complexes. Polycomb repressive complex 2 (PRC2) deposits H3K27me3, a histone mark that covers large chromatin domains. The canonical PRC1 complex can bind to PREs as well as to the H3K27me3 mark. Inside the cell nucleus, when analyzed by confocal microscopy, the PcG subunits and associated chromatin are localized to polycomb foci. However, the lack of spatial resolution of this method impedes the precise localization of the polycomb machinery relative to its target chromatin. To resolve this long-standing problem, we analyzed Drosophila embryos by superresolution stimulated emission depletion microscopy. We observed that polycomb foci associated with Hox gene clusters are composed of multiple dynamic PRC1 substructures, which we named "PRC1 nanoglobules". PREs are more associated with these nanoglobules than the surrounding H3K27me3 chromatin. By imaging the entire Bithorax complex (BX-C) locus, we identified chromatin substructures that partially overlap with PRC1 nanoglobules, indicating that they form different assemblies. Furthermore, polymer simulations suggest that interactions between PREs and PRC1 nanoglobules can drive the compaction and positioning of the BX-C domain. Taken together, these data suggest that by establishing the three-dimensional architecture of their target loci, PRC1 nanoglobules are key molecular assemblies that maintain polycomb-dependent silencing.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.