Evidence map›Paper›PMID 42409802›Full record

ReviewChinese medical journal2026

Intratumoral microbiota in tumorigenesis: A double-edged sword.

Xinyue Fu, Hao Chen, Meihang Du, Peiheng Li, Yue Zhao, Huanzuo Yang, Hancong Li, Gongshuang Zhang, Puxing He, Shuang Wu and 7 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chinese medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xinyue FuDivision of Thyroid and Parathyroid Surgery, Department of General Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Hao ChenDepartment of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Sichuan Clinical Research Center for Laboratory Medicine, Chengdu, Sichuan 610041, China.
Meihang DuDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University Cancer Centre, School of Medicine, Tongji University, Shanghai 200072, China.
Peiheng LiDivision of Thyroid and Parathyroid Surgery, Department of General Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Yue ZhaoDivision of Thyroid and Parathyroid Surgery, Department of General Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Huanzuo YangDivision of Thyroid and Parathyroid Surgery, Department of General Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Hancong LiDivision of Thyroid and Parathyroid Surgery, Department of General Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Gongshuang ZhangDivision of Thyroid and Parathyroid Surgery, Department of General Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Puxing HeDivision of Thyroid and Parathyroid Surgery, Department of General Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Shuang WuDivision of Thyroid and Parathyroid Surgery, Department of General Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Miao ZhangDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University Cancer Centre, School of Medicine, Tongji University, Shanghai 200072, China.
Zhenmei AnDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Zhihui LiDivision of Thyroid and Parathyroid Surgery, Department of General Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Binwu YingDepartment of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Sichuan Clinical Research Center for Laboratory Medicine, Chengdu, Sichuan 610041, China.
Juan Rául Hernandez SilvaInstituto Cubano de Oftalmología "Ramón Pando Ferrer", Havana, La Habana, Cuba.
Liwei AnDepartment of Stomatology, Shanghai Tenth People's Hospital, Tongji University Cancer Centre, School of Medicine, Tongji University, Shanghai 200072, China.
Han LuoDivision of Thyroid and Parathyroid Surgery, Department of General Surgery, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractThe rapid development of high-throughput sequencing technologies and bioinformatics has enabled the identification of diverse microbial communities within tumor tissues, giving rise to the concept of intratumoral microbiota. Comprising bacteria, viruses, fungi, and archaea, the intratumoral microbiota has been shown to play critical roles in tumor initiation, progression, and therapeutic responses. This review systematically summarizes the composition, ecological characteristics, and functional roles of intratumoral microbiota, with particular emphasis on its dual regulatory mechanisms in tumorigenesis, progression, metastasis, and recurrence. We further delineate four principal mechanistic pathways through which intratumoral microbiota influence tumor biology, including receptor-mediated signaling, metabolic reprogramming, effector molecule secretion, and intracellular invasion. Additionally, we evaluate the translational potential of these findings in clinical oncology, offering innovative perspectives for tumor diagnosis, therapeutic intervention, and preventive strategies.

Indexed as

CarcinogenesisMicrobiotaNeoplasmsAnimalsHumansTumor MicroenvironmentCancer progressionIntratumoral microbiotaMicrobiota-based therapyMicrobiota–immuneTumor microenvironment

Identifiers

PMID42409802
PMCPMC13593011

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.