Evidence map›Paper›PMID 42409966›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Incidence and risk factor profile for subcutaneous fat necrosis among newborns undergoing therapeutic hypothermia: a multi-center regional cohort.

Brian H Walsh, Hoda El-Shibiny, Sara Cherkerzian, Sara V Bates, Munish Gupta, Anne Hansen, Emily Herzberg, Janet S Soul, Terrie Inder, Mohamed El-Dib

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brian H WalshDepartment of Neonatology, Cork University Maternity Hospital, Cork, Ireland. brianhenry.walsh@ucc.ie.ORCID http://orcid.org/0000-0003-4665-6884
Hoda El-ShibinyDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5662-1661
Sara CherkerzianDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA.
Sara V BatesHarvard Medical School, Boston, MA, USA.
Munish GuptaHarvard Medical School, Boston, MA, USA.
Anne HansenHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7766-5188
Emily HerzbergHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7505-4543
Janet S SoulHarvard Medical School, Boston, MA, USA.
Terrie InderCenter for Neonatal Research, Children's Hospital of Orange County, Orange County, CA, USA.
Mohamed El-DibDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6979-7407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the incidence, risk factors, and outcomes associated with subcutaneous fat necrosis (SCFN) in a regional cohort of newborns treated with therapeutic hypothermia (TH) for neonatal encephalopathy (NE). STUDY

designData from a regional Neonatal Encephalopathy Registry was retrospectively analysed. All newborns treated with TH between 2018 and 2022 were included. The primary outcome was the incidence of SCFN. Secondary outcomes included associated risk factors and complications.

resultsSCFN occurred in 4% of newborns (20/499) undergoing TH. Factors associated with SCFN included elevated maternal BMI, maternal preeclampsia/hypertension, pyrexia during labor, earlier initiation of active cooling, thrombocytopenia, and blood product administration. Half of the SCFN cases developed hypercalcemia. SCFN was associated with longer hospital stay (median 11.5 vs. 8 days, p = 0.007).

conclusionIn this large, contemporary cohort, SCFN occurred in 4% of newborns with NE treated with TH. Enhanced monitoring and risk stratification may facilitate early diagnosis and improve management outcomes.

Indexed as

Fat NecrosisHypothermia, InducedSubcutaneous FatFemaleHumansHypoxia-Ischemia, BrainIncidenceInfant, NewbornLength of StayMalePregnancyRegistriesRetrospective StudiesRisk Factors

Identifiers

PMID42409966
PMCPMC13588749

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.