Evidence map›Paper›PMID 42409991›Full record

Articlenpj metabolic health and disease2026

ATP-depleting spreading depolarizations preferentially originate in the somatosensory cortex during in situ energy deprivation.

Karl Schoknecht, Nicolas G Höck, Felipe Baeza-Lehnert, Jens P Dreier, Johannes Hirrlinger, Jens Eilers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj metabolic health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karl SchoknechtCarl-Ludwig-Institute of Physiology, Medical Faculty, Leipzig University, Leipzig, Germany. karl.schoknecht@medizin.uni-leipzig.de.
Nicolas G HöckCarl-Ludwig-Institute of Physiology, Medical Faculty, Leipzig University, Leipzig, Germany.
Felipe Baeza-LehnertCarl-Ludwig-Institute of Physiology, Medical Faculty, Leipzig University, Leipzig, Germany.
Jens P DreierCentre for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Johannes HirrlingerCarl-Ludwig-Institute of Physiology, Medical Faculty, Leipzig University, Leipzig, Germany.
Jens EilersCarl-Ludwig-Institute of Physiology, Medical Faculty, Leipzig University, Leipzig, Germany.

Funding

Deutsche Forschungsgemeinschaft DR 323/10-2Deutsche Forschungsgemeinschaft HI 1414/6-1; HI 1414/7-1EMBO Long-term Fellowship ALTF382-2021
6 · The paper itself

Abstract

Spreading depolarizations (SDs) contribute to acute brain lesion development. While SDs arise in metabolically compromised tissue, regional determinants of SD-susceptibility remain incompletely understood. Here, we show that SDs preferentially originate in the primary somatosensory cortex (S1) during oxygen-glucose deprivation. Notably, before SD initiation, S1 exhibited a more pronounced decline in ATP compared with other brain regions, suggesting S1-specific metabolic vulnerability as a novel working hypothesis underlying SD initiation.

Identifiers

PMID42409991
PMCPMC13338157

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.