Evidence map›Paper›PMID 42410189›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2026

Association between sleep inertia and cognitive performance among older adults in the Wisconsin Sleep Cohort study.

Jessica J Love, Jesse D Cook, Erika W Hagen, Amanda Rasmunon, Laurel A Ravelo, Mari Palta, Paul E Peppard, David T Plante

Erratum issuedAbstract read
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In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jessica J LoveDepartment of Psychiatry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Jesse D CookDepartment of Psychiatry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Erika W HagenDepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Amanda RasmunonDepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Laurel A RaveloDepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Mari PaltaDepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Paul E PeppardDepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
David T PlanteDepartment of Psychiatry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. dplante@wisc.edu.ORCID http://orcid.org/0000-0003-2619-5654

Funding

The Role of Impaired Neurobehavioral Alertness in Cognitive Decline and Alzheimer’s Disease PathologyR01AG079352 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI David T Plante · 2023 to 2026
$3.0M
Longitudinal Associations of Midlife Sleep Duration and Quality with Later Life Cognitive and Physical Functioning DeclineR01AG058680 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI HAGEN, ERIKA W · 2018 to 2021
$2.6M
NIA NIH HHS R01 AG058680NIA NIH HHS R01AG058680NIA NIH HHS R01 AG079352US National Institutes of Health R01AG079352
6 · The paper itself

Abstract

purposeSince sleep inertia and hypersomnolence, broadly, have not been adequately studied in the context of neurocognitive performance, this investigation examined associations between sleep inertia severity, other measures of hypersomnolence, and outcomes from a standardized, cognitive testing battery in a well-characterized community-based sample of older adults.

methodsWisconsin Sleep Cohort participants completed the Sleep Inertia Questionnaire (SIQ), Epworth Sleepiness Scale (ESS), Hypersomnia Severity Index (HSI) and six widely used cognitive tests. Linear regression examined relationships between hypersomnolence measures (SIQ, ESS, and HSI) and cognitive outcomes. Secondary analyses assessed relationships between SIQ subscales (physiological, cognitive, emotional, and responses) and cognitive outcomes. Adjusted models included covariates capturing demographic, psychosocial, sleep, and testing characteristics.

resultsThe sample (N = 461) was predominantly non-Hispanic white older adults (average age = 73.84 ± 6.66 years), with majority being male (55.8%). In unadjusted analyses, SIQ total score was associated with Grooved Pegboard (GPB), Trail Making Test-Part B (TMT-B), and Symbol Digits Modalities Test, while neither ESS nor HSI was associated with cognitive outcomes. Significant associations between SIQ and GPB and TMT-B remained in fully adjusted analyses. Physiological, cognitive, and emotional SIQ subscales were also associated with cognitive tests, particularly GPB and TMT-B.

conclusionsThis study suggests that sleep inertia may be an important, specific symptom that is associated with cognitive performance in older adults. Future research is indicated to clarify the role of sleep inertia in aging, while exploring its potential value as a risk factor for cognitive impairment and target for intervention to support cognitive health. CURRENT STUDY/STUDY RATIONALE: Sleep inertia is a common sleep-related symptom, yet it remains insufficiently studied, particularly regarding neurocognitive performance. The Sleep Inertia Questionnaire (SIQ) is a validated measure of sleep inertia, but has not been studied in older populations at risk for cognitive impairment. Clarifying relationships between SIQ scores and neurocognitive outcomes may identify those at greater risk for cognitive impairment. STUDY IMPACT: Sleep inertia is a common sleep-related symptom, yet it remains insufficiently studied, particularly regarding neurocognitive performance. The Sleep Inertia Questionnaire (SIQ) is a validated measure of sleep inertia, but has not been studied in older populations at risk for cognitive impairment. Clarifying relationships between SIQ scores and neurocognitive outcomes may identify those at greater risk for cognitive impairment.

Indexed as

CognitionDisorders of Excessive SomnolenceAgedCohort StudiesFemaleHumansMaleNeuropsychological TestsSurveys and QuestionnairesWisconsinCognitive healthCognitive performanceHypersomnolenceNeurocognitionOlder adultsSleep inertia

Identifiers

PMID42410189
PMCPMC13337965

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.