Evidence map›Paper›PMID 42410232›Full record

ArticleInternational orthopaedics2026

Ischial tuberculosis: MRI and mNGS enable early diagnosis in the largest reported case series of twenty two patients.

Yongchao Li, Jianfeng Li, Heng Wang, Jun Fan, Kai Tang, Guangxuan Yan, Weijie Dong, Tinglong Lan

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Article in International orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Yongchao LiDepartment of Orthopedics, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Jianfeng LiChinese PLA Medical School, Chinese PLA General Hospital, Beijing, China.
Heng WangDepartment of Orthopedics, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Jun FanDepartment of Orthopedics, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Kai TangDepartment of Orthopedics, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Guangxuan YanDepartment of Orthopedics, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Weijie DongDepartment of Orthopedics, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Tinglong LanDepartment of Orthopedics, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China. lantinglongbjxkyy@163.com.

Funding

The 2024 Youth Project of the Open Research Fund of the State Key Laboratory of Neurology and Oncology Drug Development SKLSIM-2024108The Scientific Research Cultivation Fund of Capital Medical University PYZ24154
6 · The paper itself

Abstract

purposeTo analyze the clinical features, diagnosis, treatment, and prognosis of ischial tuberculosis (IT), and to evaluate the diagnostic value of MRI and mNGS in the largest reported case series to date.

methodsData from 22 patients with confirmed IT treated between January 2013 and January 2023 were retrospectively reviewed. Diagnosis was based on histopathology, microbiology, and molecular tests.

resultsThe mean age was 31.6 years (11 to 67). Common symptoms included gluteal pain (100.0%), sitting-induced pain (81.8%), and local swelling (59.1%). Computed tomography (CT) revealed lesions in 86.4% of patients, while magnetic resonance imaging (MRI) showed abnormalities in all 18 patients examined. The ischial tuberosity was the most common site of involvement (63.6%). The T-cell spot test for tuberculosis infection (T-SPOT.TB), Xpert Mycobacterium tuberculosis/rifampicin resistance assay (Xpert MTB/RIF), and metagenomic next-generation sequencing (mNGS) showed positivity rates of 83.3%, 83.3%, and 100%, respectively. Histopathological granulomas were observed in 77.3%. Overall, 68.2% underwent surgical debridement. All patients achieved clinical cure with no recurrence at a mean follow-up of 34.7 months.

conclusionIT has an insidious onset. MRI (100% sensitivity) is valuable for early diagnosis, and molecular tests, particularly mNGS (100% detection rate), enhance pathogen detection. Surgical debridement combined with standard chemotherapy achieved clinical cure in all patients, but comparative studies are needed to confirm its superiority over conservative treatment.

Indexed as

IschiumMagnetic Resonance ImagingTuberculosis, OsteoarticularAdolescentAdultAgedAntitubercular AgentsChildEarly DiagnosisFemaleHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedMycobacterium tuberculosisRetrospective StudiesAntitubercular AgentsIschial tuberculosisMetagenomic next-generation sequencingOsteoarticular tuberculosisRetrospective studyXpert MTB/RIF

Identifiers

PMID42410232

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.