Evidence map›Paper›PMID 42410273›Full record

ReviewDiscover nano2026

Nanodrug delivery systems enhance traditional Chinese medicine treatment of osteoporosis.

Li-Li Zhang, Yuxiang Zhou, Wei Xiong, Xiaolin Shi, Yifeng Yuan

Abstract readReview
In one paragraph

Review in Discover nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Li-Li Zhang *Department of Pathology, The Second Affiliated Hospital Zhejiang, University School of Medicine, 310009, Hangzhou, China.
Yuxiang Zhou *Rehabilitation Department, Zhoushan Guanghua Hospital, Zhejiang, 316000, Zhoushan, China.
Wei XiongThe Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310052, China.
Xiaolin ShiThe Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005, China.
Yifeng YuanThe Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005, China. 501292122@qq.com.

Funding

National Comprehensive Reform Demonstration Zone for Traditional Chinese Medicine (Zhejiang Province) Science and Technology Co-construction Project GZY-KJS-ZJ-2026-066"Pioneer" and "Leading Goose" R&D Program of Zhejiang 2025C02193,2026C02A1083
6 · The paper itself

Abstract

Osteoporosis (OP) is a prevalent chronic metabolic bone disorder characterized by decreased bone mineral density, deterioration of bone microarchitecture, and increased fracture risk. Traditional Chinese medicines (TCM) have demonstrated considerable therapeutic potential in OP management due to their osteogenic and anti-resorptive activities. However, the therapeutic efficacy of TCM is often limited by the drawbacks of conventional delivery systems, underscoring the need for advanced formulation strategies to fully exploit their potential in OP prevention and treatment. In recent years, nanomedicine has emerged as a transformative platform for drug delivery, offering new avenues to enhance the pharmacological performance of herbal medicines. Nano-based delivery systems for anti-osteoporotic herbal compounds provide multiple benefits, including protection of active ingredients from degradation, improved bioavailability, reduced gastrointestinal irritation, and superior therapeutic outcomes. This review provides a comprehensive overview of the nanocarriers employed in the delivery of TCM, summarizes the current status and therapeutic efficacy of herb-loaded nanomedicines in OP management, and discusses the challenges and future directions for clinical translation. By highlighting recent advances and addressing existing hurdles, this review aims to contribute valuable insights for optimizing TCM-based nanotherapeutics in the prevention and treatment of osteoporosis.

Indexed as

Active ingredientsNano-drug delivery systemsOsteoporosisTCMTreatment

Identifiers

PMID42410273
PMCPMC13338079

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.