ArticleDiabetes, obesity & metabolism2026
GLP-1 Receptor Agonists for Weight Loss and Risk of Major Safety Outcomes: A Multicentre Cohort Study.
Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- GLP-1 Receptor Agonists for Weight Loss and Risk of Major Safety Outcomes: A Multicentre Cohort Study.Diabetes, obesity & metabolism · 2026Article
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Authors and funding
20 authors.
Funding
Abstract
aimsGlucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for weight loss, yet their safety in clinical practice remains uncertain. We evaluated associations between weight-management semaglutide or liraglutide initiation and safety outcomes in a multicentre cohort. MATERIALS AND
methodsWe used electronic health records from 13 South Korean hospitals (2018-2025) mapped to the OMOP Common Data Model. Adults initiating semaglutide or liraglutide were compared with propensity score-matched non-initiators in a new-user design. Ten safety outcomes were assessed. Site-specific hazard ratios were estimated using Cox proportional hazards models and combined via meta-analysis.
resultsAfter matching, 2357 semaglutide and 6953 liraglutide initiators were compared with 22 602 and 68 001 non-initiators, respectively. Semaglutide was associated with increased risks of psychiatric disorders overall (hazard ratio 2.02, 95% confidence interval 1.30-3.14), anxiety disorder (2.39, 1.22-4.71), depressive disorder (3.42, 1.51-7.74), gastrointestinal dysmotility or obstruction (3.91, 1.42-10.82), and vision impairment (1.58, 1.04-2.41). Liraglutide was associated with increased risks of psychiatric disorders overall (1.66, 1.36-2.03), anxiety disorder (1.68, 1.45-1.96), depressive disorder (1.51, 1.14-2.00), hepatic impairment (1.46, 1.16-1.83), pancreatobiliary disorder (1.33, 1.09-1.63), pancreatitis/cholangitis/cholelithiasis (1.40, 1.18-1.68), and vision impairment (1.34, 1.16-1.55). Sensitivity analyses were consistent overall, although semaglutide-associated vision impairment and liraglutide-associated hepatic impairment were not significant in some analyses.
conclusionsGLP-1 RA initiation for weight loss was associated with higher risks of selected psychiatric and gastrointestinal outcomes compared with non-initiators, with heterogeneity across agents. These findings underscore the importance of careful patient selection and monitoring.
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