ReviewGenome medicine2026
Circadian regulation of cardiovascular function: from physiology to clinical implications.
Review in Genome medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian rhythms play a crucial role in maintaining cardiovascular homeostasis, orchestrating fluctuations in blood pressure, heart rate variability, endothelial function, and systemic vascular tone. Disruptions of the circadian clock -arising from ageing, genetic predisposition, or environmental and lifestyle factors- can significantly elevate the risk of cardiovascular diseases, including hypertension, atherosclerosis, heart failure, and arrhythmias. This review examines the role of circadian regulation in cardiovascular physiology, from molecular clock networks and clock-controlled gene regulation to systemic cardiovascular physiology and clinical translation. We discuss how circadian disruption affects blood pressure, heart rate variability, and vascular health, through mechanisms including inflammation, mitochondrial dysfunction, and metabolic dysregulation. We further position circadian biology within the broader context of cardiovascular ageing and the molecular mechanisms that drive age-associated cardiovascular decline.Special attention is given to the role of inflamm-ageing in promoting atherosclerosis and acute cardiovascular events, as well as the impact of desynchrony between central and peripheral clocks on disease severity. Additionally, we highlight the circadian regulation of genes implicated in cardiovascular ageing and disease. Finally, we explore emerging research on the clinical implications of circadian misalignment, with a focus on therapeutic strategies such as chronotherapy, time-restricted eating, and physical activity. By integrating current evidence, this review provides a comprehensive perspective on leveraging circadian rhythms for the prevention and management of cardiovascular diseases.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.