Evidence map›Paper›PMID 42410587›Full record

ArticleBMC pulmonary medicine2026

Characterization of mucus plugging in patients with chronic obstructive pulmonary disease: additional clinical significance of asthma-like features.

Kaoruko Shimizu, Naoya Tanabe, Susumu Sato, Shotaro Chubachi, Kazuya Tanimura, Naoya Fujino, Hiroaki Iijima, Nobuyasu Wakazono, Isao Yokota, Yuki Abe and 9 more

Abstract read
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In one paragraph

Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kaoruko ShimizuDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan. okaoru@med.hokudai.ac.jp.
Naoya TanabeDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, 54, Kawara-machi, Syogoin, Sakyo-ku, Kyoto, Japan.
Susumu SatoDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, 54, Kawara-machi, Syogoin, Sakyo-ku, Kyoto, Japan.
Shotaro ChubachiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35, Shinano-cho, Shinjuku-ku, Tokyo, Japan.
Kazuya TanimuraDepartment of Respiratory Medicine, Nara Medical University, 840, Shijyo- cho, Kashihara, Nara, Japan.
Naoya FujinoDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1, Seiryo-cho, Aoba-ku, Sendai, Japan.
Hiroaki IijimaDepartment of Respiratory Medicine, Tsukuba Medical Center, 1-3-1, Amakubo, Tsukuba, Japan.
Nobuyasu WakazonoDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.
Isao YokotaData Science Center, Promotion Unit, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital, North 14, West 5, Kita-ku, Sapporo, Japan.
Yuki AbeDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.
Keisuke KamadaDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.
Sho NakakuboDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.
Hirokazu KimuraDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.
Houman GoudarziDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.
Takeshi HattoriDepartment of Respiratory Medicine, National Hospital Organization Hokkaido Medical Center, 5-7-1-1, Yamanote, Nishi-ku, Sapporo, Japan.
Ichizo TsujinoDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.
Hironi MakitaHokkaido Institute of Respiratory Diseases, 1-4, South 7, West 2, Chuo-Ku, Sapporo, Japan.
Masaharu NishimuraHokkaido Institute of Respiratory Diseases, 1-4, South 7, West 2, Chuo-Ku, Sapporo, Japan.
Satoshi KonnoDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAsthma-like features, defined as a high blood eosinophil count (BEC), atopy, and bronchodilator reversibility, characterize patients with chronic obstructive pulmonary disease (COPD) under optimal treatment. However, whether these features contribute to the phenotype of mucus plugging has not been elucidated. In this study, we aimed to examine the functional and clinical outcomes related to mucus plugging in patients with and without asthma-like features.

methodsMucus plug score was assessed using inspiratory computed tomography (CT) scans in participants from the Hokkaido COPD cohort study who underwent CT examinations using the same protocol, were categorized based on asthma-like features, and completed the St. George's Respiratory Questionnaire (SGRQ). To evaluate the association between mucus plug score and pulmonary function indices, multivariate analyses were performed to examine the relationships between the mucus plug score and percent predicted forced expiratory volume in 1 s (%FEV

resultsThe mucus plug score was negatively associated with %FEV

conclusionsAsthma-like features may differentiate the functional role of mucus plugging observed on CT scans in patients with COPD. Further studies are needed to validate these findings and clarify the underlying pathophysiology for improved disease management.

Indexed as

AsthmaMucusPulmonary Disease, Chronic ObstructiveAgedEosinophilsFemaleForced Expiratory VolumeHumansLeukocyte CountMaleMiddle AgedMultivariate AnalysisRespiratory Function TestsTomography, X-Ray ComputedTotal Lung CapacityAsthmaChronic obstructive pulmonary diseaseComputed tomographyEosinophilMucus pluggingPercent predicted forced expiratory volume in 1 sResidual volumeTotal lung capacity

Identifiers

PMID42410587
PMCPMC13617715

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.