Evidence map›Paper›PMID 42410677›Full record

SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Dementia blood biomarkers in the context of post-stroke cognitive outcomes: Systematic review and evidence synthesis.

Hing Tim Fung, Olivia Burton, Mara Bortnowschi, Paul M Matthews, Laura M Parkes, Henrik Zetterberg, Atticus H Hainsworth, Fatemeh Geranmayeh

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hing Tim FungDepartment of Brain Sciences, Imperial College London, London, UK.
Olivia BurtonDepartment of Brain Sciences, Imperial College London, London, UK.
Mara BortnowschiDepartment of Brain Sciences, Imperial College London, London, UK.
Paul M MatthewsDepartment of Brain Sciences, Imperial College London, London, UK.
Laura M ParkesSchool of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Atticus H HainsworthCity-St George's University of London, London, UK.
Fatemeh GeranmayehDepartment of Brain Sciences, Imperial College London, London, UK.

Funding

Alzheimer's Society AS-DTC-24-004Alzheimer's Society AS-PG-23-024Alzheimer's Society VIDA - 644British Heart Foundation PG/20/10397 SP/F/22/150042European Union's Horizon Europe research and innovation programme 101053962Medical Research Council (MRC) MR/R005567/1Medical Research Council (MRC) MR/T001402/1Medical Research Council (MRC) MR/T033371/1National Institute for Health and Care Research (NIHR)Swedish Research Council #2019-02397Swedish Research Council #2022-01018Swedish Research Council #2023-00356Swedish State Support for Clinical Research #ALFGBG-71320UK Dementia Research Institute UKDRI-1003
6 · The paper itself

Abstract

introductionThe prognostic value of emerging dementia-related blood-based biomarkers for post-stroke cognitive impairment is poorly understood. We addressed this critical gap in this systematic review.

methodsFour databases were searched in March 2025 for studies of neurofilament light (NfL), glial fibrillary acidic protein (GFAP), amyloid beta (Aβ), tau, and placental growth factor (PlGF) in relation to post-stroke cognitive outcomes. Risk of bias, narrative synthesis, and meta-analysis were performed.

resultsEighteen studies were included, eleven assessing NfL. Meta-analysis of four studies (n = 2020) showed higher acute NfL was associated with worse cognition at 1-6 months (Z = -0.518, 95% confidence interval [CI] -0.684 to -0.351). Baseline GFAP was associated with worse cognition longitudinally, whereas results for amyloid and tau species were inconsistent between studies. Risk of bias was high. DISCUSSION: NfL and GFAP show the most consistent associations with post-stroke cognition, particularly acutely. Evidence for amyloid and tau was inconsistent between studies, and PlGF remains unexplored.

Indexed as

BiomarkersCognitive DysfunctionDementiaStrokeAmyloid beta-PeptidesGlial Fibrillary Acidic ProteinHumansNeurofilament ProteinsPlacenta Growth Factortau ProteinsAmyloid beta-PeptidesBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament ProteinsPlacenta Growth Factortau Proteinsamyloid betablood‐based biomarkerscognitive impairmentglial fibrillary acidic proteinhemorrhagic strokeischemic strokeneurofilament light chainplacental growth factorstrokesystematic reviewtau protein

Identifiers

PMID42410677
PMCPMC13337546

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.