Evidence map›Paper›PMID 42411057›Full record

ReviewNucleus (Austin, Tex.)2026

Nuclear mechanotransduction: tools for mechanical perturbation and chromatin characterization.

Jennifer Soto, Nolan Origer, Yifan Wu, Braulio Cardenas Benitez, Ramzi Massad, Donna Rahgoshay, Abraham Lee, Timothy Downing, Song Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nucleus (Austin, Tex.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jennifer SotoDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA.
Nolan OrigerDepartment of Biomedical Engineering, University of California Irvine, Irvine, CA, USA.
Yifan WuDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA.
Braulio Cardenas BenitezDepartment of Biomedical Engineering, University of California Irvine, Irvine, CA, USA.
Ramzi MassadDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA.
Donna RahgoshayDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA.
Abraham LeeDepartment of Biomedical Engineering, University of California Irvine, Irvine, CA, USA.
Timothy DowningDepartment of Biomedical Engineering, University of California Irvine, Irvine, CA, USA.
Song LiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA, USA.

Funding

Training Program in Stem Cell Translational Medicine for Neurological DisordersT32NS082174 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PETER John DONOVAN, Leslie Michels Thompson · 2013 to 2026
$3.3M
Mechanopriming for cell engineeringR01NS130677 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Song Li · 2023 to 2026
$2.1M
Regulation of cell reprogramming by matrix stiffnessR01GM143485 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2021 to 2024
$1.3M
NIGMS NIH HHS R01 GM143485NINDS NIH HHS R01 NS130677NINDS NIH HHS T32 NS082174
6 · The paper itself

Abstract

Mechanical cues, ranging from matrix mechanical properties to dynamic mechanical loading, can be transmitted via structural proteins and signaling molecules to the nucleus to reorganize nuclear architecture and modulate chromatin accessibility. This mechanical regulation plays an important role in tissue regeneration and disease development. To gain deeper insights into the mechanical regulation of chromatin organization, it is essential to develop technologies that can apply mechanical inputs and characterize the resulting changes in nuclear structure and chromatin organization. Here, we review multidisciplinary technologies and tools that enable mechanical perturbation of the nucleus and the characterization of nuclear and chromatin responses. We highlight how perturbations such as matrix topography, confinement, stiffness, viscoelasticity, and dynamic loading can be used to apply mechanical cues to cells. We also discuss how imaging-based techniques, sequencing platforms, and computational approaches can be integrated to characterize nuclear architecture and chromatin organization in response to these mechanical stimuli.

Indexed as

Cell NucleusChromatinMechanotransduction, CellularAnimalsHumansChromatinbiomaterialsepigenetic regulationMechanobiologymicrofluidicsnuclear mechanicssingle cell imaging

Identifiers

PMID42411057
PMCPMC13348924

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.