Evidence map›Paper›PMID 42411292›Full record

ArticleMediators of inflammation2026

Propofol and Salvianolic Acid a Synergistically Attenuate LPS-Induced Myocardial Pyroptosis in Diabetic Mice via the SIRT1/HMGB1 Pathway.

Anyuan Zhang, Ronghui Han, Kaijia Han, Ting Li, Jianyu Zhu, Yongyan Wang, Jiaqi Zhou, Jiajia Chen, Wangning Shangguan, Stanley Sau Ching Wong and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anyuan ZhangDepartment of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China, wmu.edu.cn.
Ronghui HanDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, gdmuah.com.
Kaijia HanDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, gdmuah.com.
Ting LiDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, gdmuah.com.
Jianyu ZhuDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, gdmuah.com.
Yongyan WangDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, gdmuah.com.
Jiaqi ZhouDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, gdmuah.com.
Jiajia ChenDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, gdmuah.com.
Wangning ShangguanDepartment of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China, wmu.edu.cn.
Stanley Sau Ching WongDepartment of Anaesthesiology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, hku.hk.
Weiyi XiaDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hongkong, China, polyu.edu.hk.
Guanghua ChenOrthopaedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, gdmuah.com.ORCID https://orcid.org/0000-0002-8877-1322
Zhengyuan XiaDepartment of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China, wmu.edu.cn.ORCID https://orcid.org/0000-0001-6844-5928

Funding

National Natural Science Foundation of China 82270306
6 · The paper itself

Abstract

backgroundWe investigated whether propofol (PPF) combined with salvianolic acid A (SAA) confers synergistic cardioprotection in diabetic sepsis.

methodsDiabetic-septic mice and high-glucose/LPS-treated cardiomyocytes were treated with PPF and SAA. Cardiac function, reactive oxygen species (ROS), inflammation, and the SIRT1/HMGB1 pathway were assessed.

resultsPPF combined with SAA synergistically attenuated cardiac inflammation, pyroptosis, and dysfunction, accompanied by SIRT1 upregulation and HMGB1 downregulation. Notably, low-dose coadministration of PPF (12.5 µM) and SAA (12.5 µM) achieved protection comparable to high-dose PPF (25 µM), significantly reducing ROS and pyroptosis markers. These protective effects were reversed by SIRT1 inhibition or silencing but enhanced by HMGB1 inhibition.

conclusionPPF and SAA synergistically inhibit LPS-induced myocardial pyroptosis under hyperglycemia by activating the SIRT1/HMGB1 pathway. This combination offers a potential strategy to enhance cardioprotection while minimizing anesthetic dosage.

Indexed as

Caffeic AcidsDiabetes Mellitus, ExperimentalHMGB1 ProteinLactatesLipopolysaccharidesPropofolPyroptosisSirtuin 1AnimalsMaleMiceMice, Inbred C57BLMyocytes, CardiacReactive Oxygen SpeciesSignal TransductionCaffeic AcidsHMGB1 ProteinHMGB1 protein, mouseLactatesLipopolysaccharidesPropofolReactive Oxygen Speciessalvianolic acid ASirt1 protein, mouseSirtuin 1diabetesHMGB1lipopolysaccharide (LPS)propofol (PPF)pyroptosissalvianolic acid A (SAA)SIRT1

Identifiers

PMID42411292
PMCPMC13338769

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.