Evidence map›Paper›PMID 42411779›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

The R120G knock-in mutation in αB-crystallin is insufficient to induce cardiomyopathy in mice.

Justin M Quiles, Rishith Ravindran, Samantha Ivezich, Liguo Chi, Rita H Najor, Åsa B Gustafsson

Abstract read
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In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Justin M QuilesSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States.
Rishith RavindranSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States.ORCID 0000-0002-5093-9652
Samantha IvezichSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States.ORCID 0009-0007-4005-3317
Liguo ChiSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States.
Rita H NajorSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States.
Åsa B GustafssonSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States.ORCID 0000-0001-6347-8210

Funding

Autophagy and Megamitochondria in Cardiac Aging and Heart FailureR01HL157265 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUSTAFSSON, ASA B. · 2021 to 2024
$1.9M
American Heart Association (AHA) 830983HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL157265NHLBI NIH HHS R01 HL157265
6 · The paper itself

Abstract

Alpha B-crystallin (CryAB) is a small heat-shock protein highly expressed in cardiac tissue, where it functions as a molecular chaperone that helps prevent protein aggregation, particularly under stress conditions. A missense mutation in CryAB (R120G) causes autosomal dominant cardiomyopathy in humans and is characterized by extensive protein aggregation in cardiomyocytes. To better understand the pathogenic mechanisms underlying CryAB

Indexed as

alpha-Crystallin B ChainCardiomyopathiesMutation, MissenseAnimalsDisease Models, AnimalGene Knock-In TechniquesGenetic Predisposition to DiseaseHomozygoteMaleMiceMice, Inbred C57BLMice, TransgenicMyocytes, CardiacPhenotypeProteotoxic Stressalpha-Crystallin B ChainCryab protein, mousecardiomyopathymitochondriaprotein aggregationαB-crystallin

Identifiers

PMID42411779
PMCPMC13418761

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.