Evidence map›Paper›PMID 42411823›Full record

ArticleBriefings in bioinformatics2026

K-attention: a biologically informed attention operator for data-efficient sequence-based omics modeling.

Tao Liu, Jing-Yi Li, Ziyu Chen, Chan Gu, Tong Zhou, Shi-Qi Yang, Yang Ding, Ge Gao

Abstract read
In one paragraph

Article in Briefings in bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tao Liu *College of Life Sciences, Beijing Normal University, 19 Xinjiekouwai Avenue, Beijing 100875, China.
Jing-Yi Li *Changping Laboratory, No. 28 Kexueyuan Road, Changping District, Beijing 102206, China.
Ziyu Chen *State Key Laboratory of Gene Function and Modulation Research, School of Life Sciences, Biomedical Pioneering Innovative Center (BIOPIC) and Beijing Advanced Innovation Center for Genomics (ICG), Center for Bioinformatics (CBI), Peking University, No. 5 Yiheyuan Road, Haidian District, Beijing 100871, China.
Chan GuChangping Laboratory, No. 28 Kexueyuan Road, Changping District, Beijing 102206, China.
Tong ZhouCollege of Life Sciences, Beijing Normal University, 19 Xinjiekouwai Avenue, Beijing 100875, China.ORCID 0000-0003-4911-073X
Shi-Qi YangChangping Laboratory, No. 28 Kexueyuan Road, Changping District, Beijing 102206, China.
Yang DingChangping Laboratory, No. 28 Kexueyuan Road, Changping District, Beijing 102206, China.ORCID 0000-0002-6543-4075
Ge GaoChangping Laboratory, No. 28 Kexueyuan Road, Changping District, Beijing 102206, China.ORCID 0000-0001-6470-8815

Funding

Beijing Advanced Innovation Center for Genomics at Peking UniversityNational Science and Technology Major Project 2022ZD0115004State Key Laboratory of Gene Function and Modulation Research
6 · The paper itself

Abstract

Deep learning-based modeling of omics data often suffers from insufficiency and heterogeneity of the data itself. As a step towards addressing these issues, we present K-attention, a biologically informed operator that models interactions between sequence fragments effectively and efficiently. Across both biologically informed simulated datasets and two real-world omics tasks, K-attention-based networks consistently outperform canonical convolutional neural network (CNN)- and Transformer-based models, with the largest gains observed in low-data regimes. Collectively, these results indicate that K-attention enables data-efficient and biologically grounded modeling under real-world constraints.

Indexed as

Computational BiologyDeep LearningGenomicsAlgorithmsConvolutional Neural NetworksHumanscomputational genomicsdata-efficiencysequence pattern recognition

Identifiers

PMID42411823
PMCPMC13338904

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.